Compile Data Set for Download or QSAR
Report error Found 61 Enz. Inhib. hit(s) with all data for entry = 50008977
LigandPNGBDBM50524103(CHEMBL4563459)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by microbeta scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524102(CHEMBL4542281)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by microbeta scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524107(CHEMBL4568594)
Affinity DataIC50: 17nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by microbeta scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524105(CHEMBL4524468)
Affinity DataIC50: 24nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by microbeta scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM323036(US10183947, Example 19 | 1-Ethyl-4-[({(1R,2R)-2-[4...)
Affinity DataIC50: 29nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by microbeta scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524101(CHEMBL4474619)
Affinity DataIC50: 34nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by microbeta scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM323018(US10183947, Example 3 | 1-Methyl-4-[({(1R,2R)-2-[4...)
Affinity DataIC50: 35nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by microbeta scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50512937(CHEMBL4450838)
Affinity DataIC50: 36nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by microbeta scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524106(CHEMBL4474748)
Affinity DataIC50: 47nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by microbeta scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50512931(CHEMBL4528928)
Affinity DataIC50: 59nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by microbeta scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524104(CHEMBL4543414)
Affinity DataIC50: 101nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by microbeta scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524108(CHEMBL4447921)
Affinity DataIC50: 241nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by microbeta scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524103(CHEMBL4563459)
Affinity DataIC50: 1.40E+3nMAssay Description:Substrate activity at recombinant human OATP1B1 expressed in HEK293 cells assessed as reduction in pivastatin uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524102(CHEMBL4542281)
Affinity DataIC50: 2.30E+3nMAssay Description:Substrate activity at recombinant human OATP1B1 expressed in HEK293 cells assessed as reduction in pivastatin uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524101(CHEMBL4474619)
Affinity DataIC50: 2.50E+3nMAssay Description:Substrate activity at recombinant human OATP1B1 expressed in HEK293 cells assessed as reduction in pivastatin uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524101(CHEMBL4474619)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in Escherichia coli using CEC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524101(CHEMBL4474619)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C8 expressed in Escherichia coli using luciferin-ME as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524102(CHEMBL4542281)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in Escherichia coli using BFC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524102(CHEMBL4542281)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2D6 expressed in Escherichia coli using MAMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524101(CHEMBL4474619)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C9 expressed in Escherichia coli using 7MFC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524101(CHEMBL4474619)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in Escherichia coli using BFC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524103(CHEMBL4563459)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in Escherichia coli using BFC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524101(CHEMBL4474619)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2D6 expressed in Escherichia coli using MAMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524102(CHEMBL4542281)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C19 expressed in Escherichia coli using CEC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524101(CHEMBL4474619)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C19 expressed in Escherichia coli using CEC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524103(CHEMBL4563459)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C9 expressed in Escherichia coli using 7MFC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524102(CHEMBL4542281)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C8 expressed in Escherichia coli using luciferin-ME as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524103(CHEMBL4563459)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C8 expressed in Escherichia coli using luciferin-ME as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524103(CHEMBL4563459)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in Escherichia coli using CEC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524102(CHEMBL4542281)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in Escherichia coli using CEC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524102(CHEMBL4542281)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C9 expressed in Escherichia coli using 7MFC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524103(CHEMBL4563459)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2D6 expressed in Escherichia coli using MAMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524103(CHEMBL4563459)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C19 expressed in Escherichia coli using CEC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524101(CHEMBL4474619)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human HCN4 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524102(CHEMBL4542281)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human HCN4 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524101(CHEMBL4474619)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human Kv1.5 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524102(CHEMBL4542281)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human Cav3.2 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524101(CHEMBL4474619)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human Cav3.2 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524102(CHEMBL4542281)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human Kv1.5 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524102(CHEMBL4542281)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human ERG by Ion-work assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetKv channel-interacting protein 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50524103(CHEMBL4563459)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human KChip2.2 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524103(CHEMBL4563459)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human KCNE1 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524103(CHEMBL4563459)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human Kv4.3 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524103(CHEMBL4563459)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human NaV1.5 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524102(CHEMBL4542281)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human KCNE1 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524101(CHEMBL4474619)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human Kv7.1 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524101(CHEMBL4474619)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human Kv4.3 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524102(CHEMBL4542281)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human Kv4.3 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524101(CHEMBL4474619)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human NaV1.5 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524102(CHEMBL4542281)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human NaV1.5 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
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