Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50030390
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50295478(1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)pheny...)
Affinity DataEC50:  73nMAssay Description:Reversal of MRP1-mediated doxorubicin-resistance in human 2008/MRP1 cells assessed as reduction of doxorubicin IC50 percent by halfMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50174854(N-(((1R,3S)-3-(9-chloro-3-methyl-4-oxoisoxazolo[4,...)
Affinity DataEC50:  93nMAssay Description:Reversal of MRP1-mediated doxorubicin-resistance in human HeLa-T5 cells assessed as reduction of doxorubicin IC50 percent by halfMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM23414(5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chr...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of MRP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50241084(Chrysoeriol | CHEMBL214321 | cid_5280666 | 5,7-dih...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of MRP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM15236(CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MRP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM15236(CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of MRP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50241084(Chrysoeriol | CHEMBL214321 | cid_5280666 | 5,7-dih...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MRP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM23414(5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chr...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MRP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50295478(1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)pheny...)
Affinity DataKi:  190nMAssay Description:Inhibition of MRP1 in human 2008/MRP1 cells by dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50295478(1,16-Bis[40-((6-methyl)-4H-chromen-4-on-2-yl)pheny...)
Affinity DataKi:  200nMAssay Description:Inhibition of MRP1 in human 2008/MRP1 cells by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM7462(cid_5280863 | CHEMBL150 | 3,5,7-trihydroxy-2-(4-hy...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of MRP1 transfected in human HeLa cells assessed as inhibition of [3H]LTC4 transport by rapid filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM7458(Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of MRP1 transfected in human HeLa cells assessed as inhibition of [3H]LTC4 transport by rapid filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of MRP1 transfected in human HeLa cells assessed as inhibition of [3H]LTC4 transport by rapid filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM15236(CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of MRP1 transfected in human HeLa cells assessed as inhibition of [3H]LTC4 transport by rapid filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM23419(CHEMBL9352 | (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of MRP1 transfected in human HeLa cells assessed as inhibition of [3H]LTC4 transport by rapid filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50033767(CHEMBL170405 | 3,3',4',5',7-pentahydroxy flavone |...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of MRP1 transfected in MDCK2 cells assessed as inhibition of calcein transportMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataKi:  1.32E+4nMAssay Description:Inhibition of MRP1 in human 2008/MRP1 cells by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataKi:  1.34E+4nMAssay Description:Inhibition of MRP1 in human 2008/MRP1 cells by dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataKi:  1.35E+5nMAssay Description:Inhibition of MRP1 in human 2008/MRP1 cells by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
The Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataKi:  1.40E+5nMAssay Description:Inhibition of MRP1 in human 2008/MRP1 cells by dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed