Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with all data for entry = 50033079
TargetATP-binding cassette sub-family C member 3(Human)
University Hospital Heidelberg

Curated by ChEMBL
LigandPNGBDBM50103642(CHEMBL308954 | TMC-125 | TMC 125 | 4-(6-amino-5-br...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of MRP3 expressed in MDCK2 cells assessed as cell growth inhibition by calcein and pheophorbide A efflux assaysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University Hospital Heidelberg

Curated by ChEMBL
LigandPNGBDBM50103642(CHEMBL308954 | TMC-125 | TMC 125 | 4-(6-amino-5-br...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of BCRP expressed in MDCK2 cells assessed as cell growth inhibition by calcein and pheophorbide A efflux assaysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University Hospital Heidelberg

Curated by ChEMBL
LigandPNGBDBM50103642(CHEMBL308954 | TMC-125 | TMC 125 | 4-(6-amino-5-br...)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of MDR1 expressed in MDCK2 cells assessed as inhibition of cell proliferation by calcein and pheophorbide A efflux assaysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
University Hospital Heidelberg

Curated by ChEMBL
LigandPNGBDBM50103642(CHEMBL308954 | TMC-125 | TMC 125 | 4-(6-amino-5-br...)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of MRP2 expressed in MDCK2 cells assessed as cell growth inhibition by calcein and pheophorbide A efflux assaysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University Hospital Heidelberg

Curated by ChEMBL
LigandPNGBDBM50103642(CHEMBL308954 | TMC-125 | TMC 125 | 4-(6-amino-5-br...)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of MRP1 expressed in MDCK2 cells assessed as cell growth inhibition by calcein and pheophorbide A efflux assaysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed