62 articles for thisTarget
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Article Title
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Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI.
Ataturk University
Substituted 1,2,3,4-tetrahydro-2,6-naphthyridines as factor XIa inhibitors
Bristol-Myers Squibb
Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.
Bayer Healthcare
Structural Insights into the Inhibition of Tubulin by the Antitumor Agent 4ß-(1,2,4-triazol-3-ylthio)-4-deoxypodophyllotoxin.
Huazhong Agricultural University
Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof
Senomyx
Synthesis of novel bisindolylmethanes: New carbonic anhydrase II inhibitors, docking, and 3D pharmacophore studies.
Universiti Teknologi Mara (Uitm)
Design, synthesis, biological evaluation, and molecular docking of novel benzopyran and phenylpyrazole derivatives as Akt inhibitors.
Zhejiang University
Triazinoindole analogs as potent inhibitors of a-glucosidase: synthesis, biological evaluation and molecular docking studies.
Hazara University
Nitrogen heterocycle derivatives, preparation thereof and application thereof in human therapeutics
Pierre Fabre Medicament
Iminothiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
Histone deacetylase inhibitors, process for preparation and uses thereof
Zhejiang Hisun Pharmaceutical
Synthesis of hybrid molecules of caffeine and eudistomin D and its effects on adenosine receptors.
Hokkaido University
M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. I. Normal rat bladder.
Temple University
Ligand discovery from a dopamine D3 receptor homology model and crystal structure.
University of California San Francisco
In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892.
Abbott Laboratories
Stable expression of a synthetic gene for the human motilin receptor: use in an aequorin-based receptor activation assay.
Kosan Biosciences
Structural elements of the gamma-aminobutyric acid type A receptor conferring subtype selectivity for benzodiazepine site ligands.
SynthÉLabo
Cloning and functional expression of the guinea pig neuropeptide Y Y2 receptor.
Uppsala University
Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition.
University of Bath
Pharmacological profile of YM087, a novel potent nonpeptide vasopressin V1A and V2 receptor antagonist, in vitro and in vivo.
Yamanouchi Pharmaceutical
Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue.
Max-Planck Institute For Experimental Medicine
Pharmacological comparison between [3H]GR 113808 binding sites and functional 5-HT4 receptors in neurons.
Cnrs Upr 9023
The C-terminal domain of the mGluR1 metabotropic glutamate receptor affects sensitivity to agonists.
Cns Research
Deriving the therapeutic concentrations for clozapine and haloperidol: the apparent dissociation constant of a neuroleptic at the dopamine D2 or D4 receptor varies with the affinity of the competing radioligand.
University of Toronto
Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.
Synaptic Pharmaceutical
Biochemical and pharmacological characterization of mu, delta and kappa 3 opioid receptors expressed in BE(2)-C neuroblastoma cells.
Memorial Sloan-Kettering Cancer Center
Stable expression of human H1-histamine-receptor cDNA in Chinese hamster ovary cells. Pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene.
UniversitÉ
Dynamic deconvolution of a pre-equilibrated dynamic combinatorial library of acetylcholinesterase inhibitors.
UniversitÉ
Specific binding of prostaglandin D2 to rat brain synaptic membrane. Occurrence, properties, and distribution.
Kyoto University
Affinities of fluoxetine, its enantiomers, and other inhibitors of serotonin uptake for subtypes of serotonin receptors.
Eli Lilly
Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility.
Mcmaster University
Inhibitor specificity via protein dynamics: insights from the design of antibacterial agents targeted against thymidylate synthase.
UniversitÀ