BDBM713747 2-(difluoromethyl)-5-(6-((4- (2-fluorophenyl)-1H-1,2,3- triazol-1-yl)methyl)pyridin-3- yl)-1,3,4-oxadiazole::US12202823, Example 48

SMILES Fc1ccccc1-c1cn(Cc2ccc(-c3nnc(C(F)F)o3)cn2)nn1

InChI Key InChIKey=HRXXFMSLWLFOLP-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 713747   

TargetHistone deacetylase 6(Human)
Quimatryx

US Patent
LigandPNGBDBM713747(2-(difluoromethyl)-5-(6-((4- (2-fluorophenyl)-1H-1...)
Affinity DataIC50: 24nMAssay Description:The buffer assay used in the inhibition hHDAC6 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and hHDAC6 (BPS ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
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TargetHistone deacetylase 1(Human)
Quimatryx

US Patent
LigandPNGBDBM713747(2-(difluoromethyl)-5-(6-((4- (2-fluorophenyl)-1H-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC1 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and HDAC1 (BPS B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Quimatryx

US Patent
LigandPNGBDBM713747(2-(difluoromethyl)-5-(6-((4- (2-fluorophenyl)-1H-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC2 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and HDAC2 (BPS B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Quimatryx

US Patent
LigandPNGBDBM713747(2-(difluoromethyl)-5-(6-((4- (2-fluorophenyl)-1H-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC3 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and HDAC3 (BPS B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 4(Human)
Quimatryx

US Patent
LigandPNGBDBM713747(2-(difluoromethyl)-5-(6-((4- (2-fluorophenyl)-1H-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC4 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and HDAC4 (BPS B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 5(Human)
Quimatryx

US Patent
LigandPNGBDBM713747(2-(difluoromethyl)-5-(6-((4- (2-fluorophenyl)-1H-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC5 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and HDAC5 (BPS B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Quimatryx

US Patent
LigandPNGBDBM713747(2-(difluoromethyl)-5-(6-((4- (2-fluorophenyl)-1H-1...)
Affinity DataIC50: 24nMAssay Description:The buffer assay used in the inhibition hHDAC6 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and hHDAC6 (BPS ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 7(Human)
Quimatryx

US Patent
LigandPNGBDBM713747(2-(difluoromethyl)-5-(6-((4- (2-fluorophenyl)-1H-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC7 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and HDAC7 (BPS B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Quimatryx

US Patent
LigandPNGBDBM713747(2-(difluoromethyl)-5-(6-((4- (2-fluorophenyl)-1H-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC8 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and HDAC8 (BPS B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 9(Human)
Quimatryx

US Patent
LigandPNGBDBM713747(2-(difluoromethyl)-5-(6-((4- (2-fluorophenyl)-1H-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC9 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and HDAC9 (BPS B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetPolyamine deacetylase HDAC10(Human)
Quimatryx

US Patent
LigandPNGBDBM713747(2-(difluoromethyl)-5-(6-((4- (2-fluorophenyl)-1H-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC10 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and hHDAC10 (BP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent