BDBM713712 1-(4-(5-(difluoromethyl)- 1,3,4-oxadiazol-2- yl)benzyl)quinol-2(1H)-one::US12202823, Example 14

SMILES O=c1ccc2ccccc2n1Cc1ccc(-c2nnc(C(F)F)o2)cc1

InChI Key InChIKey=JPJKGZLECVKNSZ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 713712   

TargetHistone deacetylase 6(Human)
Quimatryx

US Patent
LigandPNGBDBM713712(1-(4-(5-(difluoromethyl)- 1,3,4-oxadiazol-2- yl)be...)
Affinity DataIC50: 190nMAssay Description:The buffer assay used in the inhibition hHDAC6 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and hHDAC6 (BPS ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Quimatryx

US Patent
LigandPNGBDBM713712(1-(4-(5-(difluoromethyl)- 1,3,4-oxadiazol-2- yl)be...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC1 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and HDAC1 (BPS B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Quimatryx

US Patent
LigandPNGBDBM713712(1-(4-(5-(difluoromethyl)- 1,3,4-oxadiazol-2- yl)be...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC2 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and HDAC2 (BPS B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Quimatryx

US Patent
LigandPNGBDBM713712(1-(4-(5-(difluoromethyl)- 1,3,4-oxadiazol-2- yl)be...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC3 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and HDAC3 (BPS B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 4(Human)
Quimatryx

US Patent
LigandPNGBDBM713712(1-(4-(5-(difluoromethyl)- 1,3,4-oxadiazol-2- yl)be...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC4 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and HDAC4 (BPS B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 5(Human)
Quimatryx

US Patent
LigandPNGBDBM713712(1-(4-(5-(difluoromethyl)- 1,3,4-oxadiazol-2- yl)be...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC5 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and HDAC5 (BPS B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Quimatryx

US Patent
LigandPNGBDBM713712(1-(4-(5-(difluoromethyl)- 1,3,4-oxadiazol-2- yl)be...)
Affinity DataIC50: 190nMAssay Description:The buffer assay used in the inhibition hHDAC6 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and hHDAC6 (BPS ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 7(Human)
Quimatryx

US Patent
LigandPNGBDBM713712(1-(4-(5-(difluoromethyl)- 1,3,4-oxadiazol-2- yl)be...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC7 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and HDAC7 (BPS B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Quimatryx

US Patent
LigandPNGBDBM713712(1-(4-(5-(difluoromethyl)- 1,3,4-oxadiazol-2- yl)be...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC8 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and HDAC8 (BPS B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetHistone deacetylase 9(Human)
Quimatryx

US Patent
LigandPNGBDBM713712(1-(4-(5-(difluoromethyl)- 1,3,4-oxadiazol-2- yl)be...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC9 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and HDAC9 (BPS B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetPolyamine deacetylase HDAC10(Human)
Quimatryx

US Patent
LigandPNGBDBM713712(1-(4-(5-(difluoromethyl)- 1,3,4-oxadiazol-2- yl)be...)
Affinity DataIC50: 1.00E+4nMAssay Description:The buffer assay used in the inhibition hHDAC10 assay is: Hepes 50 mM, KCl 100 mM, Tween 20 0.001%, BSA 0.01%; pH=7.4. Study compound and hHDAC10 (BP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent