BDBM198128 4-amino-6-alkyloxy-2-benzylthiopyrimidines (5)

SMILES CC(C)COc1cc(N)nc(SCc2ccccc2)n1

InChI Key InChIKey=OIJKJZPCNCXNCF-UHFFFAOYSA-N

Data  3 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 198128   

TargetAdenosine receptor A1(Human)
Universit�� Di Napoli Federico Ii

LigandPNGBDBM198128(4-amino-6-alkyloxy-2-benzylthiopyrimidines (5))
Affinity DataEC50:  870nMpH: 7.4 T: 2°CAssay Description:Aliquots of cell membranes (30 ug proteins) were incubated at 25 °C for 180 min in 500 uL of binding buffer (50 mM Tris-HCl, 2 mM MgCl2, 2 units/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Universit�� Di Napoli Federico Ii

LigandPNGBDBM198128(4-amino-6-alkyloxy-2-benzylthiopyrimidines (5))
Affinity DataKi:  1.95E+3nM ΔG°:  -7.79kcal/molepH: 7.4 T: 2°CAssay Description:Aliquots of cell membranes (30 ug proteins) were incubated at 25 °C for 180 min in 500 uL of binding buffer (50 mM Tris-HCl, 2 mM MgCl2, 2 units/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Universit�� Di Napoli Federico Ii

LigandPNGBDBM198128(4-amino-6-alkyloxy-2-benzylthiopyrimidines (5))
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 7.4 T: 2°CAssay Description:Aliquots of cell membranes (30 ug) were incubated at 25 °C for 90 min in 500 uL of binding buffer (50 mM Tris-HCl, 2 mm MgCl2, 2 units/mL ADA, pH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Universit�� Di Napoli Federico Ii

LigandPNGBDBM198128(4-amino-6-alkyloxy-2-benzylthiopyrimidines (5))
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 7.4 T: 2°CAssay Description:Aliquots of cell membranes (90 ug) were incubated at 25 °C for 180 min in 500 uL of binding buffer (50 mM Tris-HCl, 5 mM MgCl2, 1 mM EDTA, 2 unit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details Article
PubMed