BDBM192118 2-(4-(3-(1H-indol-3-yl)-1-isonicotinoyl-4,5-dihydro-1H-pyrazol-5-yl)phenoxy) acetic acid (Q1)

SMILES OC(=O)COc1ccc(cc1)C1CC(=NN1C(=O)c1ccncc1)c1c[nH]c2ccccc12

InChI Key InChIKey=PAIBUWWMVMZYEE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 192118   

TargetAcetylcholinesterase(Human)
Aimst University

LigandPNGBDBM192118(2-(4-(3-(1H-indol-3-yl)-1-isonicotinoyl-4,5-dihydr...)
Affinity DataIC50: 2.55E+4nMT: 2°CAssay Description:Preparation of DPPH solution was adopted from Molyneux [J. Sci. Technol. 26(2):211-219] and Blois [Nature 181(4617):1199-1200] with minor modificatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Aimst University

LigandPNGBDBM192118(2-(4-(3-(1H-indol-3-yl)-1-isonicotinoyl-4,5-dihydr...)
Affinity DataIC50: 2.43E+4nMT: 2°CAssay Description:The ABTS free radical cation scavenging ability of the synthe- sized compounds was determined according to the procedure described earlier [Free Radi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Aimst University

LigandPNGBDBM192118(2-(4-(3-(1H-indol-3-yl)-1-isonicotinoyl-4,5-dihydr...)
Affinity DataIC50: 8.66E+4nMpH: 8.0 T: 2°CAssay Description:The in vitro AChE inhibitory activity was measured using the methods described earlier [Biochem. Pharmacol. 7:88-95]. Briefly, stock solutions (1mg/m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2016
Entry Details Article
PubMed