130 articles for thisTarget
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Xanthine oxidase inhibitory activity of nicotino/isonicotinohydrazides: A systematic approach from in vitro, in silico to in vivo studies.
University of Karachi
Synthesis, screening and docking of fused pyrano[3,2-d]pyrimidine derivatives as xanthine oxidase inhibitor.
Guru Nanak Dev University
Discovery and biological evaluation of some (1H-1,2,3-triazol-4-yl)methoxybenzaldehyde derivatives containing an anthraquinone moiety as potent xanthine oxidase inhibitors.
China Medical University
Synthesis and evaluation of xanthine oxidase inhibitory and antioxidant activities of 2-arylbenzo[b]furan derivatives based on salvianolic acid C.
China Pharmaceutical University
Discovery of novel curcumin derivatives targeting xanthine oxidase and urate transporter 1 as anti-hyperuricemic agents.
Soochow University
On the vasoprotective mechanisms underlying novelß-phosphorylated nitrones: Focus on free radical characterization, scavenging and NO-donation in a biological model of oxidative stress.
Aix-Marseille Universit£
Anti-gout nor-oleanane triterpenoids from the leaves of Stauntonia brachyanthera.
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)
Hydroxylated chalcones with dual properties: Xanthine oxidase inhibitors and radical scavengers.
Northern Kentucky University
9-Benzoyl 9-deazaguanines as potent xanthine oxidase inhibitors.
Universidade Estadual De Campinas
Synthesis and evaluation of 1-hydroxy/methoxy-4-methyl-2-phenyl-1H-imidazole-5-carboxylic acid derivatives as non-purine xanthine oxidase inhibitors.
Shenyang Pharmaceutical University
An oxidative coupling product of luteolin with cysteine ester and its enhanced inhibitory activity for xanthine oxidase.
Osaka City University
Discovery of xanthine oxidase inhibitors and/ora-glucosidase inhibitors by carboxyalkyl derivatization based on the flavonoid of apigenin.
Beijing Institute of Pharmacology & Toxicology
Synthesis and bioevaluation of 2-phenyl-4-methyl-1,3-selenazole-5-carboxylic acids as potent xanthine oxidase inhibitors.
Shenyang Pharmaceutical University
Synthesis and enzymic activity of some novel xanthine oxidase inhibitors. 3-Substituted 5,7-dihydroxypyrazolo(1,5-alpha)pyrimidines.
TBA
HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase.
Astrazeneca
Design, synthesis and molecular modeling of aloe-emodin derivatives as potent xanthine oxidase inhibitors.
Hainan University
Microwave assisted synthesis of naphthopyrans catalysed by silica supported fluoroboric acid as a new class of non purine xanthine oxidase inhibitors.
Guru Nanak Dev University
Lead optimization of isocytosine-derived xanthine oxidase inhibitors.
Piramal Healthcare
Trisubstituted thiophene analogues of 1-thiazolyl-2-pyrazoline, super oxidase inhibitors and free radical scavengers.
Swami Ramanand Teerth Marathwada University
Synthesis, biological evaluation, and molecular docking of N-{3-[3-(9-methyl-9H-carbazol-3-yl)-acryloyl]-phenyl}-benzamide/amide derivatives as xanthine oxidase and tyrosinase inhibitors.
Solapur University
Isocytosine-based inhibitors of xanthine oxidase: design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia.
Piramal Healthcare
Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits.
Piramal Healthcare
Radical scavenging and antioxidant activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp.
Chulabhorn Institute
Design, synthesis, and examination of neuron protective properties of alkenylated and amidated dehydro-silybin derivatives.
Pharmacy School of Wenzhou Medical College
Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers.
University of Antwerp
Makaluvamine P, a new cytotoxic pyrroloiminoquinone from Zyzzya cf. fuliginosa.
University of Salerno
Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill).
Institute For Natural Product Research and Infection Biology
Isomeric N-methyl-7-deazaguanines: synthesis, structural assignment, and inhibitory activity on xanthine oxidase.
TBA
Novel 3-O-acyl mesquitol analogues as free-radical scavengers and enzyme inhibitors: synthesis, biological evaluation and structure-activity relationship.
Institute of Chemical Technology
Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors.
Genkyotex
N-(1,3-Diaryl-3-oxopropyl)amides as a new template for xanthine oxidase inhibitors.
Indo-Soviet Friendship College of Pharmacy
Discovery of novel xanthone derivatives as xanthine oxidase inhibitors.
Second Military Medical University
Antioxidant xanthone derivatives induce cell cycle arrest and apoptosis and enhance cell death induced by cisplatin in NTUB1 cells associated with ROS.
Kaohsiung Medical University
A rational approach for the design and synthesis of 1-acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles as a new class of potential non-purine xanthine oxidase inhibitors.
Indo-Soviet Friendship College of Pharmacy
Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-(phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives.
University of Mysore
First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis.
Genkyotex
Synthesis of some 5-phenylisoxazole-3-carboxylic acid derivatives as potent xanthine oxidase inhibitors.
Shenyang Pharmaceutical University
Glutarimide alkaloids and a terpenoid benzoquinone from Cordia globifera.
Chulabhorn Research Institute
Discovery of 3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 - a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia [corrected]
Fuji Yakuhin
Chemical constituents from the aerial parts of Artemisia minor.
Chinese Academy of Sciences
Insights into the inhibition of xanthine oxidase by curcumin.
Shandong University of Technology
Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin.
University of California
Pentagalloylglucose, A Xanthine Oxidase Inhibitor from a Paraguayan Crude Drug, "Molle-I" (Schinus terebinthifolius)
TBA
Preparation of two sets of 5,6,7-trioxygenated dihydroflavonol derivatives as free radical scavengers and neuronal cell protectors to oxidative damage.
Pharmacy School of Wenzhou Medical College
Design, synthesis, and pharmacological and pharmacokinetic evaluation of 3-phenyl-5-pyridyl-1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors.
Fuji Yakuhin
ortho-dihydroxyisoflavone derivatives from aged Doenjang (Korean fermented soypaste) and its radical scavenging activity.
Amorepacific
Synthesis and cytotoxic, anti-inflammatory, and anti-oxidant activities of 2',5'-dialkoxylchalcones as cancer chemopreventive agents.
Kaohsiung Medical University
Phloroglucinols with antioxidant activity and xanthonolignoids from the heartwood of Hypericum geminiflorum.
Kaohsiung Medical University
Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors.
University of Manchester
Schiff base transition metal complexes as novel inhibitors of xanthine oxidase.
Nanjing University
Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitors.
Universidade Do Minho
An apigenin-derived xanthine oxidase inhibitor from Palhinhaea cernua.
Nanjing University
Free-radical-scavenging and xanthine oxidase inhibitory constituents from Stereospermum personatum.
Institute of Chemical Technology
Structural revision of aspernigrin A, reisolated from Cladosporium herbarum IFB-E002.
Nanjing University
Antioxidant and free-radical scavenging activity of constituents of the leaves of Tachigalia paniculata.
Università
New guaianolides and xanthine oxidase inhibitory flavonols from ajania fruticulosa
Nanjing University
Agents for the Treatment of Gout: Current Advances and Future Perspectives.
Shenyang Pharmaceutical University
Application and synthesis of thiazole ring in clinically approved drugs.
Zhengzhou University
Discovery and Characterization of Moracin C as an Anti-Gouty Arthritis/Hyperuricemia Candidate by Docking-Based Virtual Screening and Pharmacological Evaluation.
Southern Medical University
Past, present and future of xanthine oxidase inhibitors: design strategies, structural and pharmacological insights, patents and clinical trials.
Guru Nanak Dev University
Design, synthesis, and evaluation of tricyclic compounds containing phenyl-tetrazole as XOR inhibitors.
South China University of Technology
The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors.
Institute of Biological Chemistry and The Genomics Research Center
Relationship between quantum-chemical descriptors of proton dissociation and experimental acidity constants of various hydroxylated coumarins. Identification of the biologically active species for xanthine oxidase inhibition.
Università
Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors.
Shenyang Pharmaceutical University
Identification of novel xanthine oxidase inhibitors via virtual screening with enhanced characterization of molybdopterin binding groups.
Peking Union Medical College
Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.
Shenyang Pharmaceutical University
Discovery of 4-(phenoxymethyl)-1H-1,2,3-triazole derivatives as novel xanthine oxidase inhibitors.
China Medical University
Synthesis and biological evaluation of geniposide derivatives as inhibitors of hyperuricemia, inflammatory and fibrosis.
Collaborative Innovation Center of Functionalized Probes For Chemical Imaging In University of Shandong
Isolation and biological activity of azocine and azocane alkaloids.
University of Auckland
Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site.
Shenyang Pharmaceutical University
Design, synthesis and biological evaluation of 1-alkyl-5/6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.
Shenyang Pharmaceutical University
Arylsulfonyl histamine derivatives as powerful and selective α-glucosidase inhibitors.
Universidad Nacional De Rosario
Synthesis and bioevaluation of 1-phenylimidazole-4-carboxylic acid derivatives as novel xanthine oxidoreductase inhibitors.
South China University of Technology
Switching a Xanthine Oxidase Inhibitor to a Dual-Target Antagonist of P2Y
Shenyang Pharmaceutical University
Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors.
Welfide
Development of novel NLRP3-XOD dual inhibitors for the treatment of gout.
Soochow University
Pharmacological urate-lowering approaches in chronic kidney disease.
West China Hospital of Sichuan University
Design, synthesis and biological evaluation of N-(3-(1H-tetrazol-1-yl)phenyl)isonicotinamide derivatives as novel xanthine oxidase inhibitors.
China Medical University
Targeting the subpocket in xanthine oxidase: Design, synthesis, and biological evaluation of 2-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives.
Shenyang Pharmaceutical University
Design, synthesis and bioevaluation of 3-oxo-6-aryl-2,3-dihydropyridazine-4-carbohydrazide derivatives as novel xanthine oxidase inhibitors.
Shenyang Pharmaceutical University
Design, synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives as novel xanthine oxidase inhibitors.
Shenyang Pharmaceutical University
Propolis Components from Stingless Bees Collected on South Sulawesi, Indonesia, and Their Xanthine Oxidase Inhibitory Activity.
University of Shizuoka
Discovery of 2-phenylthiazole-4-carboxylic acid, a novel and potent scaffold as xanthine oxidase inhibitors.
Guangzhou General Pharmaceutical Research Institute
Synthesis and biological evaluation of new imidazole, pyrimidine, and purine derivatives and analogs as inhibitors of xanthine oxidase.
Università
Thioxo-dihydroquinazolin-one Compounds as Novel Inhibitors of Myeloperoxidase.
Emory University
X-ray crystal structure of a xanthine oxidase complex with the flavonoid inhibitor quercetin.
University of California
Synthesis and biological evaluation of pyrazolo[4,3-d]pyrimidine analogues.
Sichuan University
Xanthine oxidase inhibitory activity of constituents of Cinnamomum cassia twigs.
National Institute of Medicinal Materials
Design, synthesis and biological evaluation of novel xanthine oxidase inhibitors bearing a 2-arylbenzo[b]furan scaffold.
China Pharmaceutical University
Xanthine oxidase inhibitory activity of natural and hemisynthetic flavonoids from Gardenia oudiepe (Rubiaceae) in vitro and molecular docking studies.
Universidad Nacional De C£Rdoba
Design, synthesis and biological evaluation of 1-hydroxy-2-phenyl-4-pyridyl-1H-imidazole derivatives as xanthine oxidase inhibitors.
Shenyang Pharmaceutical University
Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout.
Soochow University
Synthesis and bioevaluation of 1-phenyl-pyrazole-4-carboxylic acid derivatives as potent xanthine oxidoreductase inhibitors.
South China University of Technology
Synthesis, structure-activity relationships, and mechanistic studies of 5-arylazo-tropolone derivatives as novel xanthine oxidase (XO) inhibitors.
Tohoku Medical and Pharmaceutical University
Design, synthesis and bioevaluation of 2-mercapto-6-phenylpyrimidine-4-carboxylic acid derivatives as potent xanthine oxidase inhibitors.
Shenyang Pharmaceutical University
Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents.
University of Beira Interior
Design, synthesis and biological evaluation of N-(4-alkoxy-3-cyanophenyl)isonicotinamide/nicotinamide derivatives as novel xanthine oxidase inhibitors.
China Medical University
Berchemiosides A-C, 2-Acetoxy-ω-phenylpentaene Fatty Acid Triglycosides from the Unripe Fruits of Berchemia berchemiifolia.
Seoul National University
Synthesis and evaluation of 1-phenyl-1H-1,2,3-triazole-4-carboxylic acid derivatives as xanthine oxidase inhibitors.
China Medical University
Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity.
University of Nis
Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia.
Guangxi Medical University
Carboxylated aurone derivatives as potent inhibitors of xanthine oxidase.
National Academy of Sciences of Ukraine
Potential anti-gout constituents as xanthine oxidase inhibitor from the fruits of Stauntonia brachyanthera.
Shenyang Pharmaceutical University
Substituted N-arylethyl-2-arylquinoline-4-carboxamides and use thereof
Bayer Aktiengesellschaft
C5-C6-oxacyclic fused iminothiazine dioxide compounds bearing an ether linker as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
Compounds and methods for modulating interleukin-2-inducible t-cell kinase
Corvus Pharmaceuticals
Chromone containing sulfonamides as potent carbonic anhydrase inhibitors.
Ondokuz Mayis University
Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA-Encoded Chemical Library.
X-Chem Pharmaceuticals
Non-ATP dependent inhibitors of extracellular signal-regulated kinase (ERK)
University of Maryland, Baltimore
Benzimidazole derivatives as new a-glucosidase inhibitors and in silico studies.
Universiti Teknologi Mara (Uitm)
Derivatives of N-acyl-N′-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes
Takeda Pharmaceutical
In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor.
Japan Tobacco
Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety.
Smithkline Beecham Pharmaceuticals