125 articles for thisTarget
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Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir.
Sankyo
Synthesis and anti-influenza virus activity of 7-O-alkylated derivatives related to zanamivir.
Sankyo
Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives.
Sankyo
Design and synthesis of 1,2,3-triazole-containing N-acyl zanamivir analogs as potent neuraminidase inhibitors.
National Tsing Hua University
A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1-N9 Neuraminidases: Insight into Neuraminidase-Inhibitor Interactions.
Thammasat University
Peramivir Phosphonate Derivatives as Influenza Neuraminidase Inhibitors.
National Taiwan University
Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors.
Academia Sinica
Design, synthesis, and biological evaluation of crenatoside analogues as novel influenza neuraminidase inhibitors.
Central South University
Inhibitory potency of flavonoid derivatives on influenza virus neuraminidase.
Freie Universitaet Berlin
Oseltamivir hydroxamate and acyl sulfonamide derivatives as influenza neuraminidase inhibitors.
TBA
Neuraminidase inhibitory activities of quaternary isoquinoline alkaloids from Corydalis turtschaninovii rhizome.
Chungnam National University
Discovery of N-substituted oseltamivir derivatives as potent and selective inhibitors of H5N1 influenza neuraminidase.
Shandong University
Benzophenone C-glucosides and gallotannins from mango tree stem bark with broad-spectrum anti-viral activity.
Chinese Academy of Sciences
Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues.
University of Alberta
Development of oseltamivir phosphonate congeners as anti-influenza agents.
The Genomics Research Center
Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: the hydrophobic side chain influences type A subtype selectivity.
University of Alabama At Birmingham
Limited inhibitory effects of oseltamivir and zanamivir on human sialidases.
Miyagi Cancer Center Research Institute
Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses.
National Taiwan University
Synergistic effect of zanamivir-porphyrin conjugates on inhibition of neuraminidase and inactivation of influenza virus.
National Taiwan University
BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.
Biocryst Pharmaceuticals
Binding constants of neuraminidase inhibitors: An investigation of the linear interaction energy method.
University of Southampton
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.
Glaxo Wellcome Research and Development
Molecular modeling studies on ligand binding to sialidase from influenza virus and the mechanism of catalysis.
Monash University
Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides.
Glaxowellcome Medicines Research Centre
Novel inhibitors of influenza sialidases related to zanamivir. Heterocyclic replacements of the glycerol sidechain
TBA
Novel inhibitors of influenza sialidases related to GG167 structure-activity, crystallographic and Molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides
TBA
Novel inhibitors of influenza sialidase related to GG167 Synthesis of 4-amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides; selective inhibitors of influenza a virus sialidase
TBA
Selective and slow-binding inhibition of shikonin derivatives isolated from Lithospermum erythrorhizon on glycosyl hydrolase 33 and 34 sialidases.
Korea Research Institute of Bioscience and Biotechnology
Synthesis and biological evaluation of sialic acid derivatives containing a long hydrophobic chain at the anomeric position and their C-5 linked polymers as potent influenza virus inhibitors.
Saitama University
The de-guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase.
University of Victoria
3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase.
Peking Union Medical College
Characteristic of alkylated chalcones from Angelica keiskei on influenza virus neuraminidase inhibition.
Korea Research Institute of Bioscience and Biotechnology
Susceptibility of highly pathogenic H5N1 influenza viruses to the neuraminidase inhibitor oseltamivir differs in vitro and in a mouse model.
St. Jude Children'S Research Hospital
Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai.
University of Innsbruck
Systematic syntheses of influenza neuraminidase inhibitors: a series of carbosilane dendrimers uniformly functionalized with thioglycoside-type sialic acid moieties.
Saitama University
Recent advances of phenotypic screening strategies in the application of anti-influenza virus drug discovery.
Shandong University
Discovery of N-substituted oseltamivir derivatives as novel neuraminidase inhibitors with improved drug resistance profiles and favorable drug-like properties.
Shandong University
The current strategies of optimization of oseltamivir against mutant neuraminidases of influenza A：A review.
Shenyang Pharmaceutical University
Conformationally locked sugar derivatives and analogues as potential neuraminidase inhibitors.
Jawaharlal Nehru University
Pterocarpan scaffold: A natural lead molecule with diverse pharmacological properties.
Texas Southern University
Natural and nature-inspired stilbenoids as antiviral agents.
Universita Degli Studi di Milano
Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors
Shandong University
Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza.
Glaxosmithkline
Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core.
Abbott Laboratories
Discovery of hydrazide-containing oseltamivir analogues as potent inhibitors of influenza A neuraminidase.
Shenyang Pharmaceutical University
Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.
Abbott Laboratories
Design, synthesis and biological evaluation of substituted flavones and aurones as potential anti-influenza agents.
Prin. K.M. Kundnani College of Pharmacy
Boronate, trifluoroborate, sulfone, sulfinate and sulfonate congeners of oseltamivir carboxylic acid: Synthesis and anti-influenza activity.
National Taiwan University
Discovery of novel 1,2,3-triazole oseltamivir derivatives as potent influenza neuraminidase inhibitors targeting the 430-cavity.
Shandong University
Potent inhibition of influenza sialidase by a benzoic acid containing a 2-pyrrolidinone substituent.
University of Alabama At Birmingham
Total synthesis of dryocrassin ABBA and its analogues with potential inhibitory activity against drug-resistant neuraminidases.
Chinese Academy of Sciences
Design, synthesis and biological evaluation of "Multi-Site"-binding influenza virus neuraminidase inhibitors.
Shandong University
Novel N-Substituted oseltamivir derivatives as potent influenza neuraminidase inhibitors: Design, synthesis, biological evaluation, ADME prediction and molecular docking studies.
The Hong Kong Polytechnic University
Discovery of novel acylhydrazone neuraminidase inhibitors.
Shanghai Institute of Technology
Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1.
Charles University
Discovery of Novel Neuraminidase Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay.
Shanghai Institute of Technology
Design, synthesis and biological evaluation of oseltamivir derivatives containing pyridyl group as potent inhibitors of neuraminidase for influenza A.
Wuyi University
1,2,3-Triazolyl-4-oxoquinolines: A feasible beginning for promising chemical structures to inhibit oseltamivir-resistant influenza A and B viruses.
Universidade Federal Fluminense
Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.
Chonbuk National University
Flavonoids from Matteuccia struthiopteris and Their Anti-influenza Virus (H1N1) Activity.
Shenyang Pharmaceutical University
Exploring human parainfluenza virus type-1 hemagglutinin-neuraminidase as a target for inhibitor discovery.
Griffith University
Design and synthesis of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidase inhibitors.
Wuhan University School of Pharmaceutical Sciences
Oseltamivir analogues bearing N-substituted guanidines as potent neuraminidase inhibitors.
Utrecht University
Computer-guided approach to access the anti-influenza activity of licorice constituents.
University of Innsbruck
Development of novel potent orally bioavailable oseltamivir derivatives active against resistant influenza A.
Christian-Albrechts University of Kiel
Further discovery of caffeic acid derivatives as novel influenza neuraminidase inhibitors.
Shandong University
Caffeic acid derivatives: a new type of influenza neuraminidase inhibitors.
Shandong University
Aspulvinones from a mangrove rhizosphere soil-derived fungus Aspergillus terreus Gwq-48 with anti-influenza A viral (H1N1) activity.
Ocean University of China
Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors.
Chinese Academy of Sciences
Enhanced anti-influenza agents conjugated with anti-inflammatory activity.
National Taiwan University
Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities.
Chinese Academy of Sciences
Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses.
Chosun University
Synthesis and in vitro study of novel neuraminidase inhibitors against avian influenza virus.
Chulalongkorn University
Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir.
National Taiwan University
Design, synthesis and biological activity of thiazolidine-4-carboxylic acid derivatives as novel influenza neuraminidase inhibitors.
Shandong University
Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata.
Chosun University
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
Daiichi Sankyo
New stilbenoid with inhibitory activity on viral neuraminidases from Erythrina addisoniae.
Chosun University
Carbocycles related to oseltamivir as influenza virus group-1-specific neuraminidase inhibitors. Binding to N1 enzymes in the context of virus-like particles.
Simon Fraser University
C-Methylated Flavonoids from Cleistocalyx operculatus and Their Inhibitory Effects on Novel Influenza A (H1N1) Neuraminidase.
Chosun University
QSAR study of flavonoids and biflavonoids as influenza H1N1 virus neuraminidase inhibitors.
Universidad De Buenos Aires
Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities.
Peking Union Medical College
Ensemble-based virtual screening reveals potential novel antiviral compounds for avian influenza neuraminidase.
University of California
Design, synthesis, inhibitory activity, and SAR studies of hydrophobic p-aminosalicylic acid derivatives as neuraminidase inhibitors.
Shandong University
QSAR study of neuraminidase inhibitors based on heuristic method and radial basis function network.
Lanzhou University
Quantitative structure activity relationship studies on thiourea analogues as influenza virus neuraminidase inhibitors.
National Institute of Pharmaceutical Education and Research (NIPER)
Design, synthesis, inhibitory activity, and SAR studies of pyrrolidine derivatives as neuraminidase inhibitors.
Shandong University
Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.
Shandong University
Design, synthesis, and evaluation of carboxyl-modified oseltamivir derivatives with improved lipophilicity as neuraminidase inhibitors.
Shenyang Pharmaceutical University
Peramivir conjugates as orally available agents against influenza H275Y mutant.
National Taiwan University
Synthesis and anti-influenza virus evaluation of triterpene-sialic acid conjugates.
Meiji Pharmaceutical University
Discovery of berberine based derivatives as anti-influenza agent through blocking of neuraminidase.
Konkuk University
Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally available prodrugs against influenza viruses.
National Taiwan University
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.
Shandong University
Discovery of C-1 modified oseltamivir derivatives as potent influenza neuraminidase inhibitors.
Shandong University
C-Methylated Flavonoid Glycosides from Pentarhizidium orientale Rhizomes and Their Inhibitory Effects on the H1N1 Influenza Virus.
Seoul National University
Discovery of (E)-1-amino-4-phenylbut-3-en-2-ol derivatives as novel neuraminidase inhibitors.
Shanghai Institute of Technology
Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro- N-acetylneuraminic Acid Derivatives.
Csiro Manufacturing
Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors
Leo Pharma
Dihydropyridinone MGAT2 inhibitors for use in the treatment of metabolic disorders
Bristol-Myers Squibb
Histone deacetylase inhibitors and compositions and methods of use thereof
Chdi Foundation
Preparation method of dihydroindene amide compounds, their pharmaceutical compositions containing compounds thereof and use as protein kinases inhibitor
Harbin Gloria Pharmaceuticals
Characterization of a guanosine-nucleotide-binding-protein-coupled receptor for pituitary adenylate-cyclase-activating polypeptide on plasma membranes from rat brain.
Georg-August-University