BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.1M data for 1.3M Compounds and 9.6K Targets. Of those, 1.5M data for 698K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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To help with training and testing AI and other models, BindingDB downloads and search results now provide the publication date and BindingDB curation date of each measurement.

27 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Pyrano[2,3,4-EBI
Polish Academy of Sciences
N-Acyl-phosphoramidates as potential novel form of gemcitabine prodrugs.EBI
Polish Academy of Sciences
The effect of 5-substitution in the pyrimidine ring of dUMP on the interaction with thymidylate synthase: molecular modeling and QSAR.EBI
Polish Academy of Sciences
New cytosine derivatives as inhibitors of DNA methylation.EBI
Polish Academy of Sciences
Open-chain half-bastadins mimic the effects of cyclic bastadins on calcium homeostasis in cultured neurons.EBI
Polish Academy of Sciences
A molecular modeling study of the interaction of 2'-fluoro-substituted analogues of dUMP/FdUMP with thymidylate synthase.EBI
Polish Academy of Sciences
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.EBI
Polish Academy of Sciences
The synthesis of nucleoside 5'-O-(1,1-dithiotriphosphates).EBI
Polish Academy of Sciences
Evaluation of influence of Ap4A analogues on Fhit-positive HEK293T cells; cytotoxicity and ability to induce apoptosis.EBI
Polish Academy of Sciences
The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT(7)R antagonists.EBI
Polish Academy of Sciences
Discovery of two novel, small-molecule inhibitors of DNA methylation.EBI
Polish Academy of Sciences
The impact of spacer structure on 5-HT7 and 5-HT1A receptor affinity in the group of long-chain arylpiperazine ligands.EBI
Polish Academy of Sciences
Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands - Fluoxetine and fluvoxamine.EBI
Polish Academy of Sciences
Rationally designed N-phenylsulfonylindoles as a tool for the analysis of the non-basic 5-HTEBI
Polish Academy of Sciences
Synthesis, crystal structure and biological activity of novel analogues of tricyclic drugs.EBI
Polish Academy of Sciences
Influence of the terminal amide fragment geometry in some 3-arylideneindolin-2(1H)-ones on their 5-HT1A/5-HT2A receptor activity.EBI
Polish Academy of Sciences
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.EBI
Polish Academy of Sciences
Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HTEBI
Polish Academy of Sciences
2-Aminoimidazole-based antagonists of the 5-HTEBI
Polish Academy of Sciences
Virtual screening-driven discovery of dual 5-HTEBI
Polish Academy of Sciences
8-[4-[2-(1,2,3,4-Tetrahydroisoquinolinyl]butyl-8-azaspiro[4.5]decane-7,9-dione: a new 5-HT1A receptor ligand with the same activity profile as buspirone.EBI
Polish Academy of Sciences
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.EBI
Polish Academy of Sciences
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.EBI
Polish Academy of Sciences
Amino Acid Hot Spots of Halogen Bonding: A Combined Theoretical and Experimental Case Study of the 5-HTEBI
Polish Academy of Sciences
Structural insights into serotonin receptor ligands polypharmacology.EBI
Polish Academy of Sciences
Structure-activity relationship studies of central nervous system agents. 5. Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3-chlorophenyl)piperazines for 5-HT1A receptor site.EBI
Polish Academy of Sciences
Imaging histone deacetylases with a radiotracer using positron emission tomographyBDB
The General Hospital