190 articles for thisTarget
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Article Title
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Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof
Dana-Farber Cancer Institute
Cyclic molecules as Bruton's tyrosine kinase inhibitor
Minghui Pharmaceutical (Shanghai)
COMPOUND FOR EGFR KINASE INHIBITOR, COMPOSITION, AND USE THEREOF
Zhejiang University
Imidazo[1,2- a]pyrazine and Imidazo[1,2- a]pyridine Based Tyrosyl-DNA Phosphodiesterase I (TDP1) Inhibitors
Department Of Health and Human Services
RADIOFLUORINATED AGENTS FOR PET IMAGING SELECTIVELY TARGETING FIBROBLAST ACTIVATION PROTEIN
Tufts College
N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV 1.7 AND/OR NAV 1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME AND KITS
Eurofarma
FUSED TETRACYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN MEDICINE
Jiangsu Hengrui Pharmaceuticals
Methods for treating neurological symptoms associated with lysosomal storage diseases
Genzyme
PYRIMIDINE OR PYRIDINE DERIVATIVES USEFUL AS HCN2 MODULATORS
King''s College London
Pyridine derivatives with c-linked cyclic substituents as cGAS inhibitors
Boehringer Ingelheim International
1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS BCL-2 INHIBITORS FOR THE TREATMENT OF NEOPLASTIC AND AUTOIMMUNE DISEASES
Newave Pharmaceutical
Dizocilpine derivatives as peripheral NMDA receptor antagonists
Institut National De La Sante Et De La Recherche Medicale (Inserm
Oxadiazaspiro compounds for the treatment of drug abuse and addiction
Esteve Pharmaceuticals
2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-7,8-dihydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one as a BTK inhibitor
Hutchison Medipharma
Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same
Hanmi Pharm.
Macrocycle containing aminopyrazole and pyrimidine and pharmaceutical composition and use thereof
Chia Tai Tianqing Pharmaceutical Group
Antibody drug conjugates of kinesin spindel protein (KSP) inhibitors with antiB7H3-antibodies
Bayer Pharma Aktiengesellschaft
Thienopyridine carboxamides as ubiquitin-specific protease inhibitors
Valo Early Discovery
Combinations comprising substituted imidazo[1,5-a]pyrazinones as PDE1 inhibitors
H. Lundbeck
Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
Array Biopharma
Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same
Hanmi Pharm.
Modulators of the 5-hydroxytryptamine receptor 7 and their method of use
Temple University
STK4 inhibitors for treatment of hematologic malignancies
Dana-Farber Cancer Institute
2,3-dihydro-isoindole-1-one derivative as BTK kinase suppressant, and pharmaceutical composition including same
Crystalgenomics
Ingenol analogs, pharmaceutical compositions and methods of use thereof
Glaxosmithkline Intellectual Property Development
Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine and cosmetics
Galderma Research & Development
Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor
Bristol-Myers Squibb
Materials and method for inhibiting replication protein A and uses thereof
Indiana University Research and Technology
C5, C6 oxacyclic-fused thiazine dioxide compounds as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
Synthesis and biological evaluation of polyhydroxy benzophenone as mushroom tyrosinase inhibitors.
Sun Yat-Sen University
Green synthesis, inhibition studies of yeast a-glucosidase and molecular docking of pyrazolylpyridazine amines.
University of The Punjab
2,5-Diaryloxadiazoles and their precursors as novel inhibitors of cathepsins B, H and L.
Kurukshetra University
Curcumin analogues as zinc chelators and their uses
The Research Foundation of State University of New York
Inhibition of HIV-1 Reverse Transcriptase Dimerization by Small Molecules.
University of Siena
1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators
Actelion Pharmaceuticals
Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase
Janssen Pharmaceutica
Chrysophaentin analogs that inhibit FtsZ protein
The United States of America, As Represented By The Secretary, Department of Health and Human Services
Inhibitor Fingerprinting of Rhomboid Proteases by Activity-Based Protein Profiling Reveals Inhibitor Selectivity and Rhomboid Autoprocessing.
Technische Universität München
2′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
Merck Sharp & Dohme
Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV.
University of Illinois At Chicago
Identification of Novel Selective Lysine-Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore-Based Virtual Screening Combined with Docking.
China Pharmaceutical University
Quinone reductase 2 is an adventitious target of protein kinase CK2 inhibitors TBBz (TBI) and DMAT.
University of Western Ontario
Synthesis, in vitro evaluation and molecular docking studies of thiazole derivatives as new inhibitors of a-glucosidase.
Hazara University
Synthesis of benzimidazole derivatives as potent ß-glucuronidase inhibitors.
Universiti Teknologi Mara (Uitm)
Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
Bristol-Myers Squibb
Compound of a reverse-turn mimetic and a production method and use therefor
Jw Pharmaceutical
N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
Abbvie
Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
Shionogi
Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
Albany Molecular Research
Phenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as BACE-1 inhibitors, compositions, and their use
Merck Sharp & Dohme
Conformationally restricted urea inhibitors of soluble epoxide hydrolase
University of California
Evaluation of 5-enolpyruvoylshikimate-3-phosphate synthase substrate and inhibitor binding by stopped-flow and equilibrium fluorescence measurements.
Monsanto Agricultural
Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the Staphylococcus aureus FabI Enzyme-Product Complex.
Stony Brook University
Rational design of quinazoline-based irreversible inhibitors of human erythrocyte purine nucleoside phosphorylase.
Arizona State University
Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L.
Epizyme
Synthesis and inhibitory activity of ureidophosphonates, against acetylcholinesterase: pharmacological assay and molecular modeling.
Institute For Advanced Studies In Basic Sciences (Iasbs)
Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue.
Duquesne University
The rabbit motilin receptor: molecular characterisation and pharmacology.
Glaxosmithkline
In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds.
Balikesir University Science & Art Faculty
Binding of KRH-594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptors.
Shinshu University
AF2 interaction with Ascaris suum body wall muscle membranes involves G-protein activation.
Pharmacia
Characterization of the diarylether sulfonylester (-)-(R)-3-(2-hydroxymethylindanyl-4-oxy)phenyl-4,4,4-trifluoro-1-sulfonate (BAY 38-7271) as a potent cannabinoid receptor agonist with neuroprotective properties.
Bayer
Extended radioligand binding profile of iloperidone: a broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders.
Novartis Pharma
Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin.
Nih
Opioid binding profiles of new hydrazone, oxime, carbazone and semicarbazone derivatives of 14-alkoxymorphinans.
Hungarian Academy of Sciences
Yeast hexokinase inhibitors designed from the 3-D enzyme structure rebuilding.
Universite Paul Sabatier
Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes.
University of North Carolina
Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores.
King'S College London
Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
Synaptic Pharmaceutical
Heteroarylimino-4-thiazolidinones as inhibitors of cartilage degradation.
University of Catania
Biological evaluation and structural determinants of p38α mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids.
Eberhard Karls University of Tuebingen
In vitro and in vivo characterization of MDL 105,212A, a nonpeptide NK-1/NK-2 tachykinin receptor antagonist.
Hoechst Marion Roussel
Characterization of cloned somatostatin receptors SSTR4 and SSTR5.
University of Pennsylvania
SR 142801, the first potent non-peptide antagonist of the tachykinin NK3 receptor.
Sanofi Recherche
Different binding affinities of NMDA receptor channel blockers in various brain regions--indication of NMDA receptor heterogeneity.
Merz
Opioid binding properties of brain and peripheral tissues: evidence for heterogeneity in opioid ligand binding sites.
Stanford University
The characterization of [3H]sulpiride binding sites in rat striatal membranes.
St, Marianna University School of Medicine
Characterization of the binding of a morphine (mu) receptor-specific ligand: Tyr-Pro-NMePhe-D-Pro-NH2, [3H]-PL17.
Burroughs Wellcome
Molecular cloning and expression of a dopamine D2 receptor from human retina.
National Institute of Neurological Disorders and Stroke
NMDA receptor agonists derived from ibotenic acid. Preparation, neuroexcitation and neurotoxicity.
Royal Danish School of Pharmacy
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
University of Toronto
Characterization of 5-hydroxytryptamine1B receptors in rat spinal cord via [125I]iodocyanopindolol binding and inhibition of [3H]-5-hydroxytryptamine release.
University of Texas
Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.
Synaptic Pharmaceutical
Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor.
Synaptic Pharmaceutical
Antagonistic properties are shifted back to agonistic properties by further N-terminal shortening of pituitary adenylate-cyclase-activating peptides in human neuroblastoma NB-OK-1 cell membranes.
UniversitÉ
Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds.
Ariad Pharmaceuticals
Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase.
University of Connecticut
Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli.
University of Tokyo