35 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
Organization
SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli.
Institut Pasteur Hellenique
4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity.
Lek Pharmaceuticals
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.
F. Hoffmann-La Roche
Design, synthesis and bioactivity evaluation of tribactam beta lactamase inhibitors.
Lek
The synthesis and lactamase inhibitory activity of 6-(carboxymethylene)penicillins and 7-(carboxymethylene)cephalosporins
TBA
TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases.
Chu Clermont-Ferrand
Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy.
Università
Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.
Wyeth Research
Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.
Wyeth Research
Mechanism of inactivation of beta-lactamases by novel 6-methylidene penems elucidated using electrospray ionization mass spectrometry.
Wyeth Research
Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases.
Southern Methodist University
Discovery of 3-aryl substituted benzoxaboroles as broad-spectrum inhibitors of serine- and metallo-β-lactamases.
Sichuan University
Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors.
Wyeth-Ayerst Research
Synthesis and biological activities of an alpha-methyl and a beta-methyl carbapenem and the corresponding unsubstituted compound.
University of Munich
β-Lactamase Inhibitors To Restore the Efficacy of Antibiotics against Superbugs.
Universidade De Santiago De Compostela
6-(1-Hydroxyalkyl))penam sulfone derivatives as inhibitors of class A and class C beta-lactamases II.
Wyeth-Ayerst Research
6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C beta-lactamases I.
Wyeth-Ayerst Research
Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-β-lactamases.
Sichuan University
Boron in drug design: Recent advances in the development of new therapeutic agents.
S£O Paulo State University
Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases.
University of Oxford
SB-202742, a novel beta-lactamase inhibitor isolated from Spondias mombin.
Smithkline Beecham Pharmaceuticals
N-aryl 3-halogenated azetidin-2-ones and benzocarbacephems, inhibitors of beta-lactamases.
Cnrs-Cercoa
Synthesis and beta-lactamase inhibitory properties of 2 beta-[(1,2,3-triazol-1-yl)methyl]-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide and related triazolyl derivatives.
TBA
In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.
University of Leeds
5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2.5]octane-8-carboxylic acid derivatives as novel JAK kinase inhibitors
Leo Pharma
Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
Ardelyx
6-(N-benzoylamino)purine as a novel and potent inhibitor of xanthine oxidase: inhibition mechanism and molecular modeling studies.
National Institute of Pharmaceutical Education and Research