BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.1M data for 1.3M Compounds and 9.6K Targets. Of those, 1.5M data for 698K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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To help with training and testing AI and other models, BindingDB downloads and search results now provide the publication date and BindingDB curation date of each measurement.

14 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Doxifluridine-conjugated 2-5A analog shows strong RNase L activation ability and tumor suppressive effect.EBI
Gifu University
Solid-phase synthesis of 5'-triphosphate 2'-5'-oligoadenylates analogs with 3'-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs.EBI
University of Montpellier
Activation of human RNase L by 2'- and 5'-O-methylphosphonate-modified oligoadenylates.EBI
Academy of Sciences of The Czech Republic
Small-molecule activators of RNase L with broad-spectrum antiviral activity.EBI
Lerner Research Institute
Synthesis, characterization, and biological properties of 8-azido- and 8-amino-substituted 2',5'-oligoadenylates.EBI
Gunma University
Replacement of the ribofuranose oxygen of 2-5A derivatives by methylene: synthesis of an aristeromycin analogue of 2-5A core 5'-monophosphate (5'-O-phosphoryladenylyl)(2'----5')adenyl(2'----5')adenosine.EBI
TBA
 
Synthesis and properties of 25 and 35 linked -oligoriboadenylatesEBI
TBA
5'-O-Dephosphorylated 2',5'-oligoadenylate (2-5A) with 8-methyladenosine at the 2'-terminus activates human RNase L.EBI
Gifu University
Rational design and evaluation of 2-((pyrrol-2-yl)methylene)thiophen-4-ones as RNase L inhibitors.EBI
Max Planck Institute of Molecular Physiology
Activation of murine RNase L by isopolar 2'-phosphonate analogues of 2',5' oligoadenylates.EBI
Academy of Sciences of The Czech Republic
Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery.EBI
Peking University Shenzhen Graduate School
Convergent synthesis of ribonuclease L-active 2',5'-oligoadenylate-peptide nucleic acids.EBI
National Institute of Diabetes and Digestive Antd Kidney Diseases
2-Methyladenosine-Substituted 2',5'-oligoadenylates: conformations, 2-5A binding and catalytic activities with human ribonuclease L.EBI
Gifu University
Synthesis and biological activities of oligo(8-bromoadenylates) as analogues of 5'-O-triphosphoadenylyl(2'----5')adenylyl(2'----5')adenosine.EBI
TBA