37 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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A Methylene Group on C-2 of 24,24-Difluoro-19-nor-1a,25-dihydroxyvitamin D3 Markedly Increases Bone Calcium Mobilization in Vivo.
University of Wisconsin-Madison
Selective inhibition of prolyl 4-hydroxylases by bipyridinedicarboxylates.
University of Wisconsin-Madison
Removal of the 26-methyl group from 19-nor-1a,25-dihydroxyvitamin D3 markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation, and transcription.
University of Wisconsin-Madison
Potentiation of ribonuclease cytotoxicity by a poly(amidoamine) dendrimer.
University of Wisconsin-Madison
A 20S combined with a 22R configuration markedly increases both in vivo and in vitro biological activity of 1a,25-dihydroxy-22-methyl-2-methylene-19-norvitamin D3.
University of Wisconsin-Madison
Thiolactone modulators of quorum sensing revealed through library design and screening.
University of Wisconsin-Madison
Acetyl-lysine analog peptides as mechanistic probes of protein deacetylases.
University of Wisconsin-Madison
Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa.
University of Wisconsin-Madison
Design, synthesis, and biological evaluation of a 1alpha,25-dihydroxy-19-norvitamin D3 analogue with a frozen A-ring conformation.
University of Wisconsin-Madison
New hydroxyethylamine HIV protease inhibitors that suppress viral replication.
University of Wisconsin-Madison
Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements.
University of Wisconsin-Madison
13,13-Dimethyl-des-C,D analogues of (20S)-1a,25-dihydroxy-2-methylene-19-norvitamin D3 (2MD): total synthesis, docking to the VDR, and biological evaluation.
University of Wisconsin-Madison
Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D(3) (2MD) selectively eliminates bone calcium mobilization activity.
University of Wisconsin-Madison
New 1alpha,25-dihydroxy-19-norvitamin D(3) compounds constrained in a single A-ring conformation: synthesis of the analogues by ring-closing metathesis route and their biological evaluation.
University of Wisconsin-Madison
13-Methyl-substituted des-C,D analogs of (20S)-1alpha,25-dihydroxy-2-methylene-19-norvitamin D3 (2MD): synthesis and biological evaluation.
University of Wisconsin-Madison
Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators.
University of Wisconsin-Madison
Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones--weak agonists.
University of Wisconsin-Madison
Development of selective FGFR1 degraders using a Rapid synthesis of proteolysis targeting Chimera (Rapid-TAC) platform.
University of Wisconsin-Madison
New 2-alkylidene 1alpha,25-dihydroxy-19-norvitamin D3 analogues of high intestinal activity: synthesis and biological evaluation of 2-(3'-alkoxypropylidene) and 2-(3'-hydroxypropylidene) derivatives.
University of Wisconsin-Madison
Development of MDM2 degraders based on ligands derived from Ugi reactions: Lessons and discoveries.
University of Wisconsin-Madison
From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators.
University of Wisconsin-Madison
Designing non-peptide peptidomimetics in the 21st century: inhibitors targeting conformational ensembles.
University of Wisconsin-Madison
Synthesis and biological evaluation of FICZ analogues as agonists of aryl hydrocarbon receptor.
University of Wisconsin-Madison
Design, combinatorial chemical synthesis and in vitro characterization of novel urea based gelatinase inhibitors.
University of Wisconsin-Madison
Synthesis of novel cyclic protease inhibitors using Grubbs olefin metathesis.
University of Wisconsin-Madison
Development of selective small molecule MDM2 degraders based on nutlin.
University of Wisconsin-Madison
Cyclosporin analogs modified in the 3,7,8-positions: substituent effects on peptidylprolyl isomerase inhibition and immunosuppressive activity are nonadditive.
University of Wisconsin-Madison
A comparative study of non-native N-acyl l-homoserine lactone analogs in two Pseudomonas aeruginosa quorum sensing receptors that share a common native ligand yet inversely regulate virulence.
University of Wisconsin-Madison
Hydroxyethylamine analogues of the p17/p24 substrate cleavage site are tight-binding inhibitors of HIV protease.
University of Wisconsin-Madison
Effect of hydroxyl group configuration in hydroxyethylamine dipeptide isosteres on HIV protease inhibition. Evidence for multiple binding modes.
University of Wisconsin-Madison
Development of Potent, Protease-Resistant Agonists of the Parathyroid Hormone Receptor with BroadĪ² Residue Distribution.
University of Wisconsin-Madison
Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation.
University of Wisconsin-Madison
