BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 748K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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22 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
The"Cyclopropyl Fragment" is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules.EBI
St. John'S University
Discovery and structure-activity relationship of novel 2,3-dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2H)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 inhibitors.EBI
St. John'S University
Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid.EBI
St. John'S University
Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents.EBI
St. John'S University
Identification of novel PARP-1 inhibitors by structure-based virtual screening.EBI
St. John'S University
CoMFA and HQSAR studies on 6,7-dimethoxy-4-pyrrolidylquinazoline derivatives as phosphodiesterase10A inhibitors.EBI
St. John'S University
Design and synthesis of substituted N-methylbenzamide analogues derived from SR 48,968 as neurokinin-2 receptor antagonists.EBI
St. John'S University
Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)polymerase-1 inhibitors.EBI
St. John'S University
Inhibition of c-Kit, VEGFR-2 (KDR), and ABCG2 by analogues of OSI-930.EBI
St. John'S University
Synthesis and pharmacological activity of 1,3,6-trisubstituted-4-oxo-1,4-dihydroquinoline-2-carboxylic acids as selective ET(A) antagonists.EBI
St. John'S University
Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin.EBI
St. John'S University
3D-QSAR studies on malonyl coenzyme A decarboxylase inhibitors.EBI
St. John'S University
Small-Molecule Gankyrin Inhibition as a Therapeutic Strategy for Breast and Lung Cancer.EBI
St. John'S University
Opportunities for Tapping into Three-Dimensional Chemical Space through a Quaternary Carbon.EBI
St. John'S University
Acetylene Group, Friend or Foe in Medicinal Chemistry.EBI
St. John'S University
Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase.EBI
St. John'S University
Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity.EBI
St. John'S University
Design, synthesis and biological evaluation of WZ4002 analogues as EGFR inhibitors.EBI
St. John'S University
Design, synthesis and biological evaluation of benzamide and phenyltetrazole derivatives with amide and urea linkers as BCRP inhibitors.EBI
St. John'S University
Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.EBI
St. John'S University
Design, synthesis and evaluation of 1,3,6-trisubstituted-4-oxo-1,4-dihydroquinoline-2-carboxylic acid derivatives as ETEBI
St. John'S University
Comprehensive Synthesis of Amino Acid-Derived Thiazole Peptidomimetic Analogues to Understand the Enigmatic Drug/Substrate-Binding Site of P-Glycoprotein.EBI
St. John'S University