Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50010695
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of EGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Electric eel)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50541071(CHEMBL4528766)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of EGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] B(Rat)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50087800((5-Benzyloxy-1H-indol-2-ylmethyl)-prop-2-ynyl-amin...)
Affinity DataIC50: 22nMAssay Description:Inhibition of Sprague-Dawley rat liver mitochondrial MAO-B using [14C]-PEA as substrate after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50541071(CHEMBL4528766)
Affinity DataIC50: 100nMAssay Description:Inhibition of human MAO-A using Tyramine hydrochloride as substrate preincubated for 30 mins followed by substrate addition and measured for 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 343nMAssay Description:Inhibition of EGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 513nMAssay Description:Inhibition of EGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCholinesterase(Horse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50541071(CHEMBL4528766)
Affinity DataIC50: 600nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50087800((5-Benzyloxy-1H-indol-2-ylmethyl)-prop-2-ynyl-amin...)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of Sprague-Dawley rat liver mitochondrial MAO-A using [14C]-5-HT as substrate after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCholinesterase(Horse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of equine serum butyrylcholinesterase using butyrylthiocholine as substrate preincubated for 60 mins followed by substrate addition by Ell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50541071(CHEMBL4528766)
Affinity DataIC50: 3.95E+3nMAssay Description:Inhibition of human MAO-B using Tyramine hydrochloride as substrate preincubated for 30 mins followed by substrate addition and measured for 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 3.18E+4nMAssay Description:Inhibition of human acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition by Ellma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 3.71E+4nMAssay Description:Inhibition of human MAO-BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human MAO-AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50087800((5-Benzyloxy-1H-indol-2-ylmethyl)-prop-2-ynyl-amin...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of butyrylcholinesterase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50087800((5-Benzyloxy-1H-indol-2-ylmethyl)-prop-2-ynyl-amin...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of acetylcholinesterase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM18627(Mifeprex | (10S,11S,14S,15S,17R)-17-[4-(dimethylam...)
Affinity DataKi:  4.70E+3nMAssay Description:Inactivation of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed