42 articles for thisTarget
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4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1.
National Institutes of Health
Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase.
National Institutes of Health
Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor.
National Institutes of Health
Virtual screening leads to the discovery of novel non-nucleotide P2Y1 receptor antagonists.
National Institutes of Health
Autoradiographic visualization of corticotropin releasing hormone type 1 receptors with a nonpeptide ligand: synthesis of [(76)Br]MJL-1-109-2.
National Institutes of Health
3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile.
National Institutes of Health
(+/-)-(N-alkylamino)benzazepine analogs: novel dopamine D1 receptor antagonists.
National Institutes of Health
Novel 4'-substituted and 4',4"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors.
National Institutes of Health
Novel 3 alpha-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles.
National Institutes of Health
A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution.
National Institutes of Health
Development of a phosphatase-stable phosphotyrosyl mimetic suitably protected for the synthesis of high-affinity Grb2 SH2 domain-binding ligands.
National Institutes of Health
Development of pyrimidone D1 dopamine receptor positive allosteric modulators.
National Institutes of Health
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.
National Institutes of Health
Lead optimization and efficacy evaluation of quinazoline-based BET family inhibitors for potential treatment of cancer and inflammatory diseases.
National Institutes of Health
Macrocyclization in the design of a conformationally constrained Grb2 SH2 domain inhibitor.
National Institutes of Health
Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C).
National Institutes of Health
(+/-)-3-[4'-(N,N-dimethylamino)cinnamyl]benzazepine analogs: novel dopamine D1 receptor antagonists.
National Institutes of Health
Hydroxylated 2-(5'-salicyl)naphthalenes as protein-tyrosine kinase inhibitors.
National Institutes of Health
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.
National Institutes of Health
Non-amine based analogues of lavendustin A as protein-tyrosine kinase inhibitors.
National Institutes of Health
Preparation of 18F-labeled muscarinic agonist with M2 selectivity.
National Institutes of Health
Syntheses and biological properties of chiral fluoroalkyl quinuclidinyl benzilates.
National Institutes of Health
Discovery and lead identification of quinazoline-based BRD4 inhibitors.
National Institutes of Health
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.
National Institutes of Health
Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro.
National Institutes of Health
1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
Incyte
Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
Merck Sharp & Dohme
Histone deacetylase inhibitors and compositions and methods of use thereof
Chdi Foundation
Novel synthesis of dihydropyrimidines for a-glucosidase inhibition to treat type 2 diabetes: in vitro biological evaluation and in silico docking.
Comsats Institute of Information Technology
Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells.
UniversitÄT WÜRzburg
Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D3.
Ligand Pharmaceuticals
Heterocyclic ITK inhibitors for treating inflammation and cancer
Confluence Life Sciences
Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.
Rheinische Friedrich-Wilhelms-Universitat Bonn