Binding Database

The following articles (labelled with PubMed ID or TBD) are for your review

PMID

Data

Article Title

Organization

Optimisation of pharmacokinetic properties to afford an orally bioavailable and selective V1A receptor antagonist.

Msd

The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists.

Msd

Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists.

Msd

Identification of potent, soluble, and orally active TRPV1 antagonists.

Msd

Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.

Msd

Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.

Msd

Identification and optimisation of novel sulfonamide, selective vasopressin V1B receptor antagonists.

Msd

Synthesis and SAR studies of novel 2-(6-aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.

Msd

Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.

Msd

The identification, and optimisation of hERG selectivity, of a mixed NET/SERT re-uptake inhibitor for the treatment of pain.

Msd

De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits.

Msd