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TargetMyosin-1 [86-782](Human)
Medshine Discovery

US Patent
LigandPNGBDBM688346(US20240189292, Compound 9)
Affinity DataIC50: 40nMAssay Description:Experiment on Inhibitory Effect of Cardiac Myosin ATPase Activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
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TargetMyosin-1 [86-782](Human)
Medshine Discovery

US Patent
LigandPNGBDBM688349(US20240189292, Compound 12)
Affinity DataIC50: 60nMAssay Description:Experiment on Inhibitory Effect of Cardiac Myosin ATPase Activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetMyosin-1 [86-782](Human)
Medshine Discovery

US Patent
LigandPNGBDBM688352(US20240189292, Compound 15)
Affinity DataIC50: 210nMAssay Description:Experiment on Inhibitory Effect of Cardiac Myosin ATPase Activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetMyosin-1 [86-782](Human)
Medshine Discovery

US Patent
LigandPNGBDBM688347(US20240189292, Compound 10)
Affinity DataIC50: 220nMAssay Description:Experiment on Inhibitory Effect of Cardiac Myosin ATPase Activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetMyosin-1 [86-782](Human)
Medshine Discovery

US Patent
LigandPNGBDBM688345(US20240189292, Compound 7)
Affinity DataIC50: 300nMAssay Description:Experiment on Inhibitory Effect of Cardiac Myosin ATPase Activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetMyosin-1(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM645010(US20240010639, Example 14 | (S)-6-((1-(2-Fluoro-5-...)
Affinity DataIC50: 350nMAssay Description:Myocardial actin (1.61 μM) and myosin motor protein S 1 fragment (0.07 μM) were mixed with different concentrations of small-molecule compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2024
Entry Details
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TargetMyosin-1(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM645002(US20240010639, Example 6 | (S)-6-((1-(5-Cyclopropy...)
Affinity DataIC50: 450nMAssay Description:Myocardial actin (1.61 μM) and myosin motor protein S 1 fragment (0.07 μM) were mixed with different concentrations of small-molecule compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2024
Entry Details
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TargetMyosin-1 [86-782](Human)
Medshine Discovery

US Patent
LigandPNGBDBM688348(US20240189292, Compound 11)
Affinity DataIC50: 510nMAssay Description:Experiment on Inhibitory Effect of Cardiac Myosin ATPase Activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetMyosin-1(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM645006(US20240010639, Example 10)
Affinity DataIC50: 620nMAssay Description:Myocardial actin (1.61 μM) and myosin motor protein S 1 fragment (0.07 μM) were mixed with different concentrations of small-molecule compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2024
Entry Details
Go to US Patent

TargetMyosin-1(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM645005(US20240010639, Example 9 | (S)-6-((l-(2,3-Dihydro-...)
Affinity DataIC50: 680nMAssay Description:Myocardial actin (1.61 μM) and myosin motor protein S 1 fragment (0.07 μM) were mixed with different concentrations of small-molecule compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2024
Entry Details
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TargetMyosin-1 [86-782](Human)
Medshine Discovery

US Patent
LigandPNGBDBM688341(US20240189292, Compound 3)
Affinity DataIC50: 730nMAssay Description:Experiment on Inhibitory Effect of Cardiac Myosin ATPase Activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetMyosin-1(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM645008(US20240010639, Example 12 | (S)-6-((1-(2-Fluoro-5-...)
Affinity DataIC50: 810nMAssay Description:Myocardial actin (1.61 μM) and myosin motor protein S 1 fragment (0.07 μM) were mixed with different concentrations of small-molecule compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2024
Entry Details
Go to US Patent

TargetMyosin-1(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM645009(US20240010639, Example 13 | (S)-6-((1-(2-Fluoro-5-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Myocardial actin (1.61 μM) and myosin motor protein S 1 fragment (0.07 μM) were mixed with different concentrations of small-molecule compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2024
Entry Details
Go to US Patent

TargetMyosin-1(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM645012(US20240010639, Example 16 | (S)-6-((1-(2-Fluoro-5-...)
Affinity DataIC50: 1.06E+3nMAssay Description:Myocardial actin (1.61 μM) and myosin motor protein S 1 fragment (0.07 μM) were mixed with different concentrations of small-molecule compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2024
Entry Details
Go to US Patent

TargetMyosin-1 [86-782](Human)
Medshine Discovery

US Patent
LigandPNGBDBM688350(US20240189292, Compound 13)
Affinity DataIC50: 1.08E+3nMAssay Description:Experiment on Inhibitory Effect of Cardiac Myosin ATPase Activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetMyosin-1(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM645011(US20240010639, Example 15 | (S)-6-((1-(3-((6-Methy...)
Affinity DataIC50: 1.13E+3nMAssay Description:Myocardial actin (1.61 μM) and myosin motor protein S 1 fragment (0.07 μM) were mixed with different concentrations of small-molecule compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2024
Entry Details
Go to US Patent

TargetMyosin-1 [86-782](Human)
Medshine Discovery

US Patent
LigandPNGBDBM688351(US20240189292, Compound 14)
Affinity DataIC50: 1.19E+3nMAssay Description:Experiment on Inhibitory Effect of Cardiac Myosin ATPase Activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
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TargetMyosin-1(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM645003(US20240010639, Example 7 | (S)-6-((1-(Bicyclo[4.2....)
Affinity DataIC50: 1.33E+3nMAssay Description:Myocardial actin (1.61 μM) and myosin motor protein S 1 fragment (0.07 μM) were mixed with different concentrations of small-molecule compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2024
Entry Details
Go to US Patent

TargetMyosin-1(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM645007(US20240010639, Example 11 | (S)-6-((1-(5-Fluoro-2,...)
Affinity DataIC50: 1.39E+3nMAssay Description:Myocardial actin (1.61 μM) and myosin motor protein S 1 fragment (0.07 μM) were mixed with different concentrations of small-molecule compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2024
Entry Details
Go to US Patent

TargetMyosin-1(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM645000(US20240010639, Example 4 | (S)-3-Isopropyl-6-((1-(...)
Affinity DataIC50: 1.66E+3nMAssay Description:Myocardial actin (1.61 μM) and myosin motor protein S 1 fragment (0.07 μM) were mixed with different concentrations of small-molecule compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2024
Entry Details
Go to US Patent

TargetMyosin-1 [86-782](Human)
Medshine Discovery

US Patent
LigandPNGBDBM688344(US20240189292, Compound 6)
Affinity DataIC50: 1.71E+3nMAssay Description:Experiment on Inhibitory Effect of Cardiac Myosin ATPase Activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetMyosin-1(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM645001(US20240010639, Example 5 | (S)-3-Isopropyl-6-((1-(...)
Affinity DataIC50: 1.98E+3nMAssay Description:Myocardial actin (1.61 μM) and myosin motor protein S 1 fragment (0.07 μM) were mixed with different concentrations of small-molecule compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2024
Entry Details
Go to US Patent

TargetMyosin-1 [86-782](Human)
Medshine Discovery

US Patent
LigandPNGBDBM688343(US20240189292, Compound 5)
Affinity DataIC50: 2.08E+3nMAssay Description:Experiment on Inhibitory Effect of Cardiac Myosin ATPase Activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetMyosin-1 [86-782](Human)
Medshine Discovery

US Patent
LigandPNGBDBM688342(US20240189292, Compound 4)
Affinity DataIC50: 2.20E+3nMAssay Description:Experiment on Inhibitory Effect of Cardiac Myosin ATPase Activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetMyosin-1(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM644997(US20240010639, Example 1 | 6-(((S)-1-(2-Fluoro-5-(...)
Affinity DataIC50: 2.41E+3nMAssay Description:Myocardial actin (1.61 μM) and myosin motor protein S 1 fragment (0.07 μM) were mixed with different concentrations of small-molecule compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2024
Entry Details
Go to US Patent

TargetMyosin-1(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM644998(US20240010639, Example 2 | 6-(((S)-1-(2-Fluoro-5-(...)
Affinity DataIC50: 2.55E+3nMAssay Description:Myocardial actin (1.61 μM) and myosin motor protein S 1 fragment (0.07 μM) were mixed with different concentrations of small-molecule compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2024
Entry Details
Go to US Patent

TargetMyosin-1(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM645004(US20240010639, Example 8 | (S)-6-((1-(2,3-Dihydrob...)
Affinity DataIC50: 3.75E+3nMAssay Description:Myocardial actin (1.61 μM) and myosin motor protein S 1 fragment (0.07 μM) were mixed with different concentrations of small-molecule compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2024
Entry Details
Go to US Patent

TargetMyosin-1 [86-782](Human)
Medshine Discovery

US Patent
LigandPNGBDBM688340(US20240189292, Compound 2)
Affinity DataIC50: 3.97E+3nMAssay Description:Experiment on Inhibitory Effect of Cardiac Myosin ATPase Activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetMyosin-1(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM644999(US20240010639, Example 3 | 3-Isopropyl-6-(((1S)-1-...)
Affinity DataIC50: 5.11E+3nMAssay Description:Myocardial actin (1.61 μM) and myosin motor protein S 1 fragment (0.07 μM) were mixed with different concentrations of small-molecule compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2024
Entry Details
Go to US Patent

TargetMyosin-1 [86-782](Human)
Medshine Discovery

US Patent
LigandPNGBDBM688339(US20240189292, Compound 1)
Affinity DataIC50: 1.40E+4nMAssay Description:Experiment on Inhibitory Effect of Cardiac Myosin ATPase Activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent