Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 12768
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726561(US20250084039, Compound HSN356)
Affinity DataKd:  6.70nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
Ligand Info
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Date in BDB:
7/16/2025
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TargetReceptor-type tyrosine-protein kinase FLT3 [F691L](Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726564(US20250084039, Compound HSN248)
Affinity DataKd:  100nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
Ligand Info
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Date in BDB:
7/16/2025
Entry Details
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TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726564(US20250084039, Compound HSN248)
Affinity DataKd:  330nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
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TargetReceptor-type tyrosine-protein kinase FLT3 [F691L](Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726567(US20250084039, Compound HSN431)
Affinity DataKd:  57nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
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TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726567(US20250084039, Compound HSN431)
Affinity DataKd:  4.80nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
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TargetReceptor-type tyrosine-protein kinase FLT3 [F691L](Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726566(US20250084039, Compound HSN459)
Affinity DataKd:  17nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
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TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726566(US20250084039, Compound HSN459)
Affinity DataKd:  5.60nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
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TargetReceptor-type tyrosine-protein kinase FLT3 [F691L](Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726565(US20250084039, Compound HSN461)
Affinity DataKd:  91nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
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TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726565(US20250084039, Compound HSN461)
Affinity DataKd:  7.90nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
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TargetReceptor-type tyrosine-protein kinase FLT3 [F691L](Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM50422748(CHEMBL5269280 | US20250084039, Compound HSN286)
Affinity DataKd:  110nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2025
Entry Details
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TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM50422748(CHEMBL5269280 | US20250084039, Compound HSN286)
Affinity DataKd:  26nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2025
Entry Details
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TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726562(US20250084039, Compound HSN334)
Affinity DataKd:  19nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
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TargetReceptor-type tyrosine-protein kinase FLT3 [F691L](Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726561(US20250084039, Compound HSN356)
Affinity DataKd:  28nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM50422748(CHEMBL5269280 | US20250084039, Compound HSN286)
Affinity DataKd:  6nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2025
Entry Details
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TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726564(US20250084039, Compound HSN248)
Affinity DataKd:  330nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
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TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726564(US20250084039, Compound HSN248)
Affinity DataKd:  47nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
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TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726563(US20250084039, Compound HSN178)
Affinity DataKd:  450nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
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TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726563(US20250084039, Compound HSN178)
Affinity DataKd:  53nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
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TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726562(US20250084039, Compound HSN334)
Affinity DataKd:  120nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726562(US20250084039, Compound HSN334)
Affinity DataKd:  19nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726562(US20250084039, Compound HSN334)
Affinity DataKd:  5.10nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726561(US20250084039, Compound HSN356)
Affinity DataKd:  19nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726561(US20250084039, Compound HSN356)
Affinity DataKd:  6.70nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726561(US20250084039, Compound HSN356)
Affinity DataKd:  1.30nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM50422748(CHEMBL5269280 | US20250084039, Compound HSN286)
Affinity DataKd:  120nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM50422748(CHEMBL5269280 | US20250084039, Compound HSN286)
Affinity DataKd:  27.6nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent