Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 8847
TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423170(US10501440, Example 2)
Affinity DataIC50: 0.300nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423180(US10501440, Example 10 | N-[(5R)-1-Amino-3-methyl-...)
Affinity DataIC50: 0.400nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423169(US10501440, Example 1 | N-[(5R)-1-Amino-5H,6H,7H-c...)
Affinity DataIC50: 0.5nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
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Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423183(US10501440, Example 13 | N-[(5R)-1-Amino-5H,6H,7H-...)
Affinity DataIC50: 0.5nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423185(US10501440, Example 15 | N-[(5R)-1-Amino-3-methyl-...)
Affinity DataIC50: 0.5nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423195(US10501440, Example 24 | 1-[2-Methyl-6-((1S,5R,6R)...)
Affinity DataIC50: 0.600nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423179(US10501440, Example 9 | N-[(5R)-1-Amino-5H,6H,7H-c...)
Affinity DataIC50: 0.600nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423171(US10501440, Example 3)
Affinity DataIC50: 0.700nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423173(US10501440, Example 4)
Affinity DataIC50: 0.800nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423174(US10501440, Example 5)
Affinity DataIC50: 0.800nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423175(US10501440, Example 6)
Affinity DataIC50: 1nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423189(US10501440, Example 19 | N-[(5R)-1-Amino-5H,6H,7H-...)
Affinity DataIC50: 1nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423187(US10501440, Example 17 | N-[(5R)-1-Amino-3-methyl-...)
Affinity DataIC50: 1nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423193(US10501440, Example 22 | N-[(5R)-1-Amino-5H,6H,7H-...)
Affinity DataIC50: 1.10nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423176(US10501440, Example 7)
Affinity DataIC50: 1.10nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423188(US10501440, Example 18 | N-[(5R)-1-Amino-3-methyl-...)
Affinity DataIC50: 1.20nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423197(US10501440, Example 26 | 1-[6-(5-Aza-spiro[2.3]hex...)
Affinity DataIC50: 1.20nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423192(US10501440, Example 21 | N-[(5R)-1-Amino-3-methyl-...)
Affinity DataIC50: 1.40nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423181(US10501440, Example 11)
Affinity DataIC50: 1.70nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423182(US10501440, Example 12)
Affinity DataIC50: 1.90nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423184(US10501440, Example 14)
Affinity DataIC50: 2nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423196(US10501440, Example 25 | 1-[6-(2-Aza-spiro[3.3]hep...)
Affinity DataIC50: 2.10nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423191(US10501440, Example 20 | N-[(5R)-1-Amino-5H,6H,7H-...)
Affinity DataIC50: 3.90nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423186(US10501440, Example 16 | N-[(5R)-1-Amino-5H,6H,7H-...)
Affinity DataIC50: 5.30nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423177(US10501440, Example 8)
Affinity DataIC50: 5.5nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423194(US10501440, Example 23 | N-[(5R)-1-Amino-5H,6H,7H-...)
Affinity DataIC50: 9.90nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423171(US10501440, Example 3)
Affinity DataKi:  0.300nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423183(US10501440, Example 13 | N-[(5R)-1-Amino-5H,6H,7H-...)
Affinity DataKi:  0.300nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423170(US10501440, Example 2)
Affinity DataKi:  0.300nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423169(US10501440, Example 1 | N-[(5R)-1-Amino-5H,6H,7H-c...)
Affinity DataKi:  0.300nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423173(US10501440, Example 4)
Affinity DataKi:  0.400nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423174(US10501440, Example 5)
Affinity DataKi:  0.400nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423179(US10501440, Example 9 | N-[(5R)-1-Amino-5H,6H,7H-c...)
Affinity DataKi:  0.400nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423180(US10501440, Example 10 | N-[(5R)-1-Amino-3-methyl-...)
Affinity DataKi:  0.400nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423185(US10501440, Example 15 | N-[(5R)-1-Amino-3-methyl-...)
Affinity DataKi:  0.400nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423187(US10501440, Example 17 | N-[(5R)-1-Amino-3-methyl-...)
Affinity DataKi:  0.5nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423188(US10501440, Example 18 | N-[(5R)-1-Amino-3-methyl-...)
Affinity DataKi:  0.5nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423182(US10501440, Example 12)
Affinity DataKi:  0.600nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423184(US10501440, Example 14)
Affinity DataKi:  1.10nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423181(US10501440, Example 11)
Affinity DataKi:  1.5nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423176(US10501440, Example 7)
Affinity DataKi:  1.90nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423186(US10501440, Example 16 | N-[(5R)-1-Amino-5H,6H,7H-...)
Affinity DataKi:  2.20nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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