Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50044814
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataKd:  1.09E+3nMAssay Description:Binding affinity to N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031315(CHEMBL3358028)
Affinity DataKd:  910nMAssay Description:Binding affinity to N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031315(CHEMBL3358028)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031320(CHEMBL3358030)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031321(CHEMBL3358029)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM43255(1-(3,6-dichloro-9-carbazolyl)-3-[2-(3H-indol-3-yl)...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031331(CHEMBL3358016)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031325(CHEMBL3358023)
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031329(CHEMBL3358017)
Affinity DataIC50: 1.56E+4nMAssay Description:Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031328(CHEMBL3358020)
Affinity DataIC50: 2.07E+4nMAssay Description:Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031327(CHEMBL3358021)
Affinity DataIC50: 2.96E+4nMAssay Description:Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataIC50: 3.71E+4nMAssay Description:Inhibition of PRMT1 (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031322(CHEMBL3358027)
Affinity DataIC50: 7.09E+4nMAssay Description:Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031318(CHEMBL1911321)
Affinity DataIC50: 8.09E+4nMAssay Description:Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031323(CHEMBL1557883)
Affinity DataIC50: 8.41E+4nMAssay Description:Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of G9a (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of SUV39H1 (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of MLL1 (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETD7(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of SET7/9 (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 3B(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of DNMT3B (unknown origin) incubated for 15 mins before addition of [3H]-SAM and poly(dI-dC).poly(dI-dC) by liquid scintillation counting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 3A(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of DNMT3A (unknown origin) incubated for 15 mins before addition of [3H]-SAM and poly(dI-dC).poly(dI-dC) by liquid scintillation counting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed