BDBM50198782 ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine)::7-(2,6-dichlorophenyl)-5-methyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)benzo[e][1,2,4]triazin-3-amine::7-(2,6-dichlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)-phenyl]-1,2,4-benzotriazin-3-amine::CHEMBL230686::TG-100435::US8481536, 367::US8481536, 575

SMILES Cc1cc(cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12)-c1c(Cl)cccc1Cl

InChI Key InChIKey=OTTCBLPTHPBEEX-UHFFFAOYSA-N

Data  19 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50198782   

TargetTyrosine-protein kinase Yes(Human)
Targegen

US Patent
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataIC50: 10.3nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataIC50: 14nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataIC50: 130nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Targegen

US Patent
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataIC50: 10nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataIC50: 11nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataIC50: 9.40nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
Go to US Patent

TargetEphrin type-B receptor 4(Human)
Targegen

US Patent
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataIC50: 40nMT: 2°CAssay Description:EphB4 kinase activity was similarly measured, using the luciferase-based technique described above. 28.9 mU/well EphB4 (Upstate) was reacted with 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Targegen

US Patent
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataIC50: 15nMAssay Description:Pdgfrβ (0.16 ug/well, Panvera/Invitrogen) 500 nM ATP and the PTK2 peptide (700 uM) were combined with compound and reaction buffer as noted abov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  11nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Targegen

US Patent
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  12.9nMAssay Description:Inhibition of Yes kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Targegen

US Patent
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  12.9nMAssay Description:Inhibition of Yes by luminescence based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  19.4nMAssay Description:Inhibition of Abl by luminescence based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  19.4nMAssay Description:Inhibition of Abl kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  20nMAssay Description:Binding affinity to Abl (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  20nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  25.9nMAssay Description:Inhibition of LynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  25.9nMAssay Description:Inhibition of Lyn by luminescence based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  28.1nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  28.1nMAssay Description:Inhibition of Src by luminescence based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  29.4nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  29.4nMAssay Description:Inhibition of Lck by luminescence based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Targegen

US Patent
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  63.8nMAssay Description:Inhibition of EphB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Targegen

US Patent
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  63.8nMAssay Description:Inhibition of EphB4 by luminescence based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  407nMAssay Description:Inhibition of RetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  493nMAssay Description:Inhibition of FGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  784nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Targegen

US Patent
LigandPNGBDBM50198782(US8481536, 367 | 7-(2,6-dichlorophenyl)-5-methyl-N...)
Affinity DataKi:  2.09E+3nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed