BDBM25470 N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide::cid_5056270::pyridine-thiazole, 1

SMILES O=C(Nc1nc(cs1)-c1ccncc1)C1COc2ccccc2O1

InChI Key InChIKey=QKKGSTFAKMXWFE-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 25470   

TargetRho-associated protein kinase 2 [1-543,T431N](Human)
The Scripps Research Institute

LigandPNGBDBM25470(cid_5056270 | N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl...)
Affinity DataIC50: 7.20nMpH: 7.0 T: 2°CAssay Description:Assays were performed using the STK2 kinase system from Cisbio. Reaction mixture containing STK2 substrate, ATP and test compound was added to the we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2008
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
The Scripps Research Institute

LigandPNGBDBM25470(cid_5056270 | N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl...)
Affinity DataIC50: 637nMpH: 7.3 T: 2°CAssay Description:Reaction mixture of kemptide, ATP, and test compound was added to the wells using a BioRAPTR FRD Workstation (Aurora Discovery). Reaction was started...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase MRCK alpha(Human)
The Scripps Research Institute

LigandPNGBDBM25470(cid_5056270 | N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl...)
Affinity DataIC50: 4.85E+3nMpH: 7.3 T: 2°CAssay Description:The mixture of a S6-peptide, ATP, and test compound was added to the wells using a BioRAPTR FRD Workstation (Aurora Discovery). Reaction was started ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2008
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
The Scripps Research Institute

LigandPNGBDBM25470(cid_5056270 | N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl...)
Affinity DataIC50: 2.00E+4nMpH: 7.3 T: 2°CAssay Description:The mixture of a S6-peptide, ATP, and test compound was added to the wells using a BioRAPTR FRD Workstation (Aurora Discovery). Reaction was started ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2008
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
The Scripps Research Institute

LigandPNGBDBM25470(cid_5056270 | N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl...)
Affinity DataIC50: 682nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2011
Entry Details
PCBioAssay
TargetRho-associated protein kinase 2(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM25470(cid_5056270 | N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl...)
Affinity DataIC50: 3.03nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetGlucose-6-phosphate 1-dehydrogenase(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM25470(cid_5056270 | N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl...)
Affinity DataIC50: 8.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2011
Entry Details
PCBioAssay
TargetGlucose-6-phosphate dehydrogenase-6-phosphogluconolactonase(Plasmodium falciparum 3D7)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM25470(cid_5056270 | N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl...)
Affinity DataIC50: 5.27E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2011
Entry Details
PCBioAssay
TargetGlucose-6-phosphate dehydrogenase-6-phosphogluconolactonase(Plasmodium falciparum 3D7)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM25470(cid_5056270 | N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl...)
Affinity DataIC50: 8.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2012
Entry Details
PCBioAssay
TargetGlucose-6-phosphate dehydrogenase-6-phosphogluconolactonase(Plasmodium falciparum 3D7)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM25470(cid_5056270 | N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl...)
Affinity DataIC50: 2.24E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2012
Entry Details
PCBioAssay
TargetRho-associated protein kinase 1(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM25470(cid_5056270 | N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl...)
Affinity DataIC50: 13nMAssay Description:Inhibition of N-terminal GST-tagged ROCK1 (1 to 535) (unknown origin) using KKRPQRRSNVF as substrate after 1 hr by Z-Lyte-based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM25470(cid_5056270 | N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Aurora-A (unknown origin) using KKRPQRRSNVF as substrate by Z-Lyte-based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM25470(cid_5056270 | N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of N-terminal GST-tagged ROCK2 (1 to 552) (unknown origin) using KKRPQRRSNVF as substrate after 1 hr by Z-Lyte-based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM25470(cid_5056270 | N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of ROCK2 (unknown origin) using C-terminus recombinant MBS (654-880 residues) as substrate incubated for 30 mins in presence of ATP by ELI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed