BDBM23269 (2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide::Cinnamic hydroxamate deriv., 13::US10188756, Compound CN87::US11505523, Compound PCI34051

SMILES COc1ccc(\C=C\C(=O)NO)cc1

InChI Key InChIKey=BQDLTSGIXOYYHY-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 23269   

TargetHistone deacetylase 9(Human)
The General Hospital

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 7.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 55.7nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 11(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetPolyamine deacetylase HDAC10(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 4(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 7.5nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetBotulinum neurotoxin type A2 [1-425](Clostridium botulinum)
The Scripps Research Institute

LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 7.90E+4nMpH: 7.4 T: 2°CAssay Description:Recombinant BoNT LC/A activity was measured in black 96-well microtiter plates by use of a Molecular Devices (Sunnyvale, CA) SpectraMax GeminiEM plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2008
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 2.57E+3nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 7(Human)
The General Hospital

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 7.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 23.2nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 5(Human)
The General Hospital

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 1.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 4(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 7.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 238nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 833nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
City of Hope

US Patent
LigandPNGBDBM23269((2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide |...)
Affinity DataIC50: 301nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent