BDBM50544833 PSMA-617::US20240366813, Compound PSMA-617::Vipivotide tetraxetan

SMILES O=C(O)CC[C@H](NC(=O)N[C@@H](CCCCNC(=O)[C@H](Cc2ccc1ccccc1c2)NC(=O)C4CCC(CNC(=O)CN3CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC3)CC4)C(=O)O)C(=O)O

InChI Key InChIKey=JBHPLHATEXGMQR-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50544833   

TargetGlutamate carboxypeptidase 2(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50544833(Vipivotide tetraxetan | PSMA-617 | US20240366813, ...)
Affinity DataIC50: 11nMAssay Description:Displacement of [125I]MIP-1095 from PSMA in human PC3-PIP cells after 1 hr by gamma counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50544833(Vipivotide tetraxetan | PSMA-617 | US20240366813, ...)
Affinity DataKd:  0.00200nMAssay Description:A Biacore 8K (Cytiva) instrument was used to determine the binding affinity of disclosed compounds to the PSMA protein (Sinobiological). The PSMA pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

TargetGlutamate carboxypeptidase 2(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50544833(Vipivotide tetraxetan | PSMA-617 | US20240366813, ...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed