BDBM430624 Beta-D-N4-hydroxycytidine::EIDD-1931::N(4)-Hydroxycytidine::N4-Hydroxycytidine::NHC::US20240034730, Compound EIDD-1931::US20240166680, Compound NHC::Uridine, 4-oxime

SMILES C1=CN(C(=O)N=C1NO)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O

InChI Key InChIKey=XCUAIINAJCDIPM-UHFFFAOYSA-N

Data  4 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 430624   

TargetOrf1a protein(MERS-CoV)
University of North Carolina At Chapel Hill

LigandPNGBDBM430624(NHC | EIDD-1931 | N4-Hydroxycytidine | Uridine, 4-...)
Affinity DataIC50: 150nMAssay Description:At 48 hours prior to infection, Calu-3 2B4 cells were plated in a 96-well black-walled clear bottom plate at 5x104 cells/well. A 10 mM stock of NHC w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of North Carolina At Chapel Hill

LigandPNGBDBM430624(NHC | EIDD-1931 | N4-Hydroxycytidine | Uridine, 4-...)
Affinity DataIC50: 300nMAssay Description:Vero E6 cells were plated at 20,000 cells/well in a 96-well plate. 24hr later, medium containing a dose response of NHC was added concurrent with SAR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of North Carolina At Chapel Hill

LigandPNGBDBM430624(NHC | EIDD-1931 | N4-Hydroxycytidine | Uridine, 4-...)
Affinity DataIC50: 80nMAssay Description:Calu-3 2B4 cells were adsorbed with MOI 0.1 PFU/cell of SARS-CoV-2 (2019-nCoV/USA-WA1/2020 strain) at 37°C. Plates were manually rocked every 10 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of North Carolina At Chapel Hill

LigandPNGBDBM430624(NHC | EIDD-1931 | N4-Hydroxycytidine | Uridine, 4-...)
Affinity DataIC50: 90nMAssay Description:Calu-3 2B4 cells were adsorbed with MOI 0.1 PFU/cell of SARS-CoV-2 (2019-nCoV/USA-WA1/2020 strain) at 37°C. Plates were manually rocked every 10 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of North Carolina At Chapel Hill

LigandPNGBDBM430624(NHC | EIDD-1931 | N4-Hydroxycytidine | Uridine, 4-...)
Affinity DataEC50:  300nMAssay Description:To evaluate the anti-HSV activity of 1, 17 or Brequinar by plaque reduction assays (PRA), Vero cells were seeded in 24-well plates at a density of 70...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetSpike glycoprotein(2019-nCoV)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM430624(NHC | EIDD-1931 | N4-Hydroxycytidine | Uridine, 4-...)
Affinity DataEC50:  300nMAssay Description:Determination of the inhibitory activity of compounds on the replication of 2019 novel coronavirus (SARS-CoV-2): anti-novel coronavirus activity test...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2024
Entry Details
Go to US Patent