BDBM97675 BDBM698786::US8476284, 43::US8497277, 15::US9133201, 15::US9181263, 2::US9278100, 2

SMILES CN(C)C\C=C\C(=O)N1CCC[C@H](C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12

InChI Key InChIKey=IDIZKFVKMFGLPN-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 97675   

TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97675(BDBM698786 | US8497277, 15 | US9181263, 2 | US9278...)
Affinity DataIC50: 2.5nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2013
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97675(BDBM698786 | US8497277, 15 | US9181263, 2 | US9278...)
Affinity DataIC50: 2.5nMpH: 7.4Assay Description:Measurements were performed in a reaction volume of 50 μL using 96-well assay plates. Kinase enzyme, inhibitor, ATP (at the Km for the kinase), an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2013
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97675(BDBM698786 | US8497277, 15 | US9181263, 2 | US9278...)
Affinity DataIC50: 2.5nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97675(BDBM698786 | US8497277, 15 | US9181263, 2 | US9278...)
Affinity DataIC50: 1.10nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97675(BDBM698786 | US8497277, 15 | US9181263, 2 | US9278...)
Affinity DataIC50: 48.8nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97675(BDBM698786 | US8497277, 15 | US9181263, 2 | US9278...)
Affinity DataIC50: 1.10nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97675(BDBM698786 | US8497277, 15 | US9181263, 2 | US9278...)
Affinity DataIC50: 48.8nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97675(BDBM698786 | US8497277, 15 | US9181263, 2 | US9278...)
Affinity DataIC50: 1.10nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97675(BDBM698786 | US8497277, 15 | US9181263, 2 | US9278...)
Affinity DataIC50: 48.8nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent