BDBM726972 US20250084096, Compound 13a::tert-butyl (S)-2-(4-(4-(but-1-yn- 1-yl)phenyl)-2,3,9-trimethyl- 6H-thieno[3,2-f][1,2,4] triazolo[4,3-a][1,4] diazepin-6-yl)acetate

SMILES CCC#Cc1ccc(C2=N[C@@H](CC(=O)OC(C)(C)C)c3nnc(C)n3-c3sc(C)c(C)c32)cc1

InChI Key InChIKey=RIXDCFTVACLMKC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 726972   

TargetBromodomain-containing protein 4 [58-164](Human)
Genentech

US Patent
LigandPNGBDBM726972(tert-butyl (S)-2-(4-(4-(but-1-yn- 1-yl)phenyl)-2,3...)
Affinity DataIC50: 23.4nMAssay Description:Binding of his6-tagged BRD4_BD1 bromodomain or his6-tagged BRD4_BD2 to a biotinylated bromodomain ligand (Compound C) was monitored by time resolved ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/17/2025
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [348-457](Human)
Genentech

US Patent
LigandPNGBDBM726972(tert-butyl (S)-2-(4-(4-(but-1-yn- 1-yl)phenyl)-2,3...)
Affinity DataIC50: 28.7nMAssay Description:Binding of his6-tagged BRD4_BD1 bromodomain or his6-tagged BRD4_BD2 to a biotinylated bromodomain ligand (Compound C) was monitored by time resolved ...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In Depth
Date in BDB:
7/17/2025
Entry Details
Go to US Patent