BDBM726724 US20250084096, Compound 2a::tert-butyl (S)-2-(2,3,9- trimethyl-4-(4-(3- (methylamino)prop-1-yn-1- yl)phenyl)-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a][1,4] diazepin-6-yl)acetate

SMILES CNCC#Cc1ccc(C2=N[C@@H](CC(=O)OC(C)(C)C)c3nnc(C)n3-c3sc(C)c(C)c32)cc1

InChI Key InChIKey=YHCKKMGTLMEGHY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 726724   

TargetBromodomain-containing protein 4 [58-164](Human)
Genentech

US Patent
LigandPNGBDBM726724(tert-butyl (S)-2-(2,3,9- trimethyl-4-(4-(3- (methy...)
Affinity DataIC50: 14.4nMAssay Description:Binding of his6-tagged BRD4_BD1 bromodomain or his6-tagged BRD4_BD2 to a biotinylated bromodomain ligand (Compound C) was monitored by time resolved ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/17/2025
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [348-457](Human)
Genentech

US Patent
LigandPNGBDBM726724(tert-butyl (S)-2-(2,3,9- trimethyl-4-(4-(3- (methy...)
Affinity DataIC50: 17.1nMAssay Description:Binding of his6-tagged BRD4_BD1 bromodomain or his6-tagged BRD4_BD2 to a biotinylated bromodomain ligand (Compound C) was monitored by time resolved ...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In Depth
Date in BDB:
7/17/2025
Entry Details
Go to US Patent