BDBM726564 US20250084039, Compound HSN248

SMILES Cc1ccc(C(=O)NCCN2CCCCC2)cc1C#Cc1c(N)ncc2ccc(Cl)cc12

InChI Key InChIKey=RGYFGAMRGAIATA-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 726564   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726564(US20250084039, Compound HSN248)
Affinity DataKd:  47nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726564(US20250084039, Compound HSN248)
Affinity DataKd:  330nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726564(US20250084039, Compound HSN248)
Affinity DataKd:  330nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [F691L](Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726564(US20250084039, Compound HSN248)
Affinity DataKd:  100nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent