BDBM726561 US20250084039, Compound HSN356

SMILES CC1C=CC(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)=CC1C#CC1=C2C=CC=NC2C(N)N=C1

InChI Key InChIKey=YCMZKLWOUILHQH-UHFFFAOYSA-N

Data  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 726561   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726561(US20250084039, Compound HSN356)
Affinity DataKd:  1.30nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726561(US20250084039, Compound HSN356)
Affinity DataKd:  6.70nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726561(US20250084039, Compound HSN356)
Affinity DataKd:  19nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726561(US20250084039, Compound HSN356)
Affinity DataKd:  6.70nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [F691L](Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM726561(US20250084039, Compound HSN356)
Affinity DataKd:  28nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent