BDBM719049 Preparation of N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-2-(5-fluoropyridin-3-yl)-5,6,7,8-tetrahydropyrido [3,4-d]pyrimidin-4-amine::US12221439, Example 30

SMILES Fc1cncc(-c2nc3c(c(NCCc4c[nH]c5ccc(F)cc45)n2)CCNC3)c1

InChI Key InChIKey=JHPMYGQJNDGEDR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 719049   

TargetCytochrome P450 1A1(Human)
Jaguahr Therapeutics

US Patent
LigandPNGBDBM719049(Preparation of N-(2-(5-fluoro-1H-indol-3-yl)ethyl)...)
Affinity DataIC50: 316nMAssay Description:The direct CYP1A1 inhibitory activity of test compounds was also assessed using the Promega P450-Glo assay system. Seven concentrations of test compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2025
Entry Details
Go to US Patent