BDBM719020 5-(4-((2-(1H-indol-3-yl)ethyl)amino)-7-(cyanomethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)nicotinonitrile::US12221439, Example 3

SMILES N#CCN1CCc2c(nc(-c3cncc(C#N)c3)nc2NCCc2c[nH]c3ccccc23)C1

InChI Key InChIKey=AXMAODQPXCLGGZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 719020   

TargetCytochrome P450 1A1(Human)
Jaguahr Therapeutics

US Patent
LigandPNGBDBM719020(5-(4-((2-(1H-indol-3-yl)ethyl)amino)-7-(cyanomethy...)
Affinity DataIC50: 158nMAssay Description:The direct CYP1A1 inhibitory activity of test compounds was also assessed using the Promega P450-Glo assay system. Seven concentrations of test compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2025
Entry Details
Go to US Patent