BDBM717611 US20250034169, Compound 78

SMILES C#Cc1nc(-c2cc(O)cc(Cl)c2C2CC2)c(F)c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc(N3CC4CCC(C4)C3)c12

InChI Key InChIKey=HMRQCNHZTPKFHM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 717611   

TargetGTPase KRas [G12D]/RAF proto-oncogene serine/threonine-protein kinase(Human)
Sunshine Lake Pharma Co.

US Patent
LigandPNGBDBM717611(US20250034169, Compound 78)
Affinity DataIC50: 7.5nMAssay Description:(1) Compound was prepared with DMSO, and diluted by 3-fold gradient with DMSO.(2) 0.1 μl of serial dilutions of the compound was added to a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Sunshine Lake Pharma Co.

US Patent
LigandPNGBDBM717611(US20250034169, Compound 78)
Affinity DataIC50: 17.3nMAssay Description:(1) Compound was prepared with DMSO, and diluted by 3-fold gradient with DMSO.(2) 0.1 μl of serial dilutions of the compound was added to a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent