BDBM709772 2-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]ethyl}-6-[(2H3)methyloxy] (4, 4-2H2)-3,4-dihydro-2,7-naphthyridin-1 (2H)-one::US12180213, Example 107

SMILES [2H]C([2H])([2H])Oc1cc2c(cn1)C(=O)N(CCN1CCN(c3nsc4ccccc34)CC1)CC2([2H])[2H]

InChI Key InChIKey=FOQOXYFYHFUCMT-YRYIGFSMSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 709772   

Target5-hydroxytryptamine receptor 1A(Human)
Sumitomo Pharma

US Patent
LigandPNGBDBM709772(2-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...)
Affinity DataKi:  0.0800nMAssay Description:Binding inhibition rate for 5-HT1A receptor (%)=100−100×{(Binding amount of [3H]8-OH-DPAT in the presence of test compound)}−(Binding amount of [3H]8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
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Target5-hydroxytryptamine receptor 2A(Human)
Sumitomo Pharma

US Patent
LigandPNGBDBM709772(2-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...)
Affinity DataKi:  0.400nMAssay Description:Binding inhibition rate for 5-HT1A receptor (%)=100−100×{(Binding amount of [3H]8-OH-DPAT in the presence of test compound)}−(Binding amount of [3H]8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Sumitomo Pharma

US Patent
LigandPNGBDBM709772(2-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...)
Affinity DataKi:  244nMAssay Description:Binding inhibition rate for 5-HT1A receptor (%)=100−100×{(Binding amount of [3H]8-OH-DPAT in the presence of test compound)}−(Binding amount of [3H]8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
Go to US Patent