BDBM683172 4-(5-(4- aminopiperidin- 1-yl)-8-(5-fluoro- 3-methylbenzo[d] isoxazol-6-yl) imidazolo[1,2-c] pyrimidin-7-yl)-2- fluorobenzonitrile::US20240216357, Example 125

SMILES Cc1noc2cc(c(F)cc12)-c1c(nc(N2CCC(N)CC2)n2ccnc12)-c1ccc(C#N)c(F)c1

InChI Key InChIKey=RTBISKBTOXWFJP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 683172   

TargetLysine-specific histone demethylase 1A(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM683172(US20240216357, Example 125 | 4-(5-(4- aminopiperid...)
Affinity DataIC50: 0.350nMAssay Description:The effects of compounds on LSD1 enzyme activity are detected by an HTRF technology to evaluate their inhibition levels on LSD1 enzyme activity. Firs...More data for this Ligand-Target Pair
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Date in BDB:
10/11/2024
Entry Details
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TargetCytochrome P450 3A4(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM683172(US20240216357, Example 125 | 4-(5-(4- aminopiperid...)
Affinity DataIC50: 4.99E+4nMAssay Description:Using mixed human liver microsomes as a CYP 450 enzyme source, specific probe substrates of respective CYP isoenzymes (2 substrates for CYP 3A4) are ...More data for this Ligand-Target Pair
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Date in BDB:
10/11/2024
Entry Details
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM683172(US20240216357, Example 125 | 4-(5-(4- aminopiperid...)
Affinity DataIC50: 9.52E+3nMAssay Description:A manual patch-clamp technology is used to evaluate whether the test compound has a potential inhibitory effect on a voltage-gated potassium ion chan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
Go to US Patent