BDBM683131 4-(4-cyano-3- fluorophenyl)-5-(3- hydroxy-4- methoxyphenyl)- 2-(4-(methylamino) piperidin-1-yl) nicotinonitrile hydrochloride::US20240216357, Example 79

SMILES CNC1CCN(CC1)c1ncc(-c2ccc(OC)c(O)c2)c(-c2ccc(C#N)c(F)c2)c1C#N

InChI Key InChIKey=PCVVXANLDDUJNB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 683131   

TargetLysine-specific histone demethylase 1A(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM683131(US20240216357, Example 79 | 4-(4-cyano-3- fluoroph...)
Affinity DataIC50: 0.300nMAssay Description:The effects of compounds on LSD1 enzyme activity are detected by an HTRF technology to evaluate their inhibition levels on LSD1 enzyme activity. Firs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
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TargetCytochrome P450 3A4(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM683131(US20240216357, Example 79 | 4-(4-cyano-3- fluoroph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Using mixed human liver microsomes as a CYP 450 enzyme source, specific probe substrates of respective CYP isoenzymes (2 substrates for CYP 3A4) are ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM683131(US20240216357, Example 79 | 4-(4-cyano-3- fluoroph...)
Affinity DataIC50: 4.38E+3nMAssay Description:A manual patch-clamp technology is used to evaluate whether the test compound has a potential inhibitory effect on a voltage-gated potassium ion chan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
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