BDBM668419 US20240124478, Example 30

SMILES CN1CCC[C@H]1COc1nc2OC3(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C=C)c1ccccc1-c1ccccc31

InChI Key InChIKey=KUMHHDKCMMCGET-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 668419   

TargetGTPase KRas [G12C,G12C,C51S,C80L,C118S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM668419(US20240124478, Example 30)
Affinity DataIC50: 68.6nMAssay Description:Biotinylated KRAS G12C protein (SEQ ID NO: 1) is diluted to 2 μM in an EDTA buffer (20 mM HEPES, 150 mM sodium chloride, 10 mM EDTA, and 0.01% T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
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