BDBM668391 US20240124478, Example 13a

SMILES C[C@H]1CN(CCN1c1nc(OC[C@@H]2CCCN2C)nc2OC3(CCCc4ccccc34)CCc12)C(=O)C=C

InChI Key InChIKey=RHXQGCNSOXWAIJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 668391   

TargetGTPase KRas [G12C,G12C,C51S,C80L,C118S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM668391(US20240124478, Example 13a)
Affinity DataIC50: 576nMAssay Description:Biotinylated KRAS G12C protein (SEQ ID NO: 1) is diluted to 2 μM in an EDTA buffer (20 mM HEPES, 150 mM sodium chloride, 10 mM EDTA, and 0.01% T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent