BDBM668390 2-((2S)-1-acryloyl- 4-(2'-((1- ((dimethylamino) methyl) cyclopropyl) methoxy)-3,4, 5',6'-tetrahydro- 2H-spiro [naphthalene-1,7'- pyrano[2,3- d]pyrimidin]-4'- yl)piperazin- 2-yl)acetonitrile::US20240124478, Example 12b

SMILES CN(C)CC1(COc2nc3O[C@]4(CCCc5ccccc45)CCc3c(n2)N2CCN([C@@H](CC#N)C2)C(=O)C=C)CC1

InChI Key InChIKey=BZNKSZJYWNCYDL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 668390   

TargetGTPase KRas [G12C,G12C,C51S,C80L,C118S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM668390(US20240124478, Example 12b | 2-((2S)-1-acryloyl- 4...)
Affinity DataIC50: 728nMAssay Description:Biotinylated KRAS G12C protein (SEQ ID NO: 1) is diluted to 2 μM in an EDTA buffer (20 mM HEPES, 150 mM sodium chloride, 10 mM EDTA, and 0.01% T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
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