BDBM620422 US11767305, Compound R-5-MAPB::US20250019357, Compound R-(-)-5-MAPB

SMILES CN[C@H](C)Cc1ccc2occc2c1

InChI Key InChIKey=ZOVRTIPCNFERHY-UHFFFAOYSA-N

Data  1 KI  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 620422   

TargetSodium-dependent serotonin transporter(Human)
Tactogen

US Patent
LigandPNGBDBM620422(US11767305, Compound R-5-MAPB | US20250019357, Com...)
Affinity DataIC50: 150nMAssay Description:For the SERT uptake inhibition assay, 5 nM [3H]5-HT was used. To optimize uptake for a single transporter, unlabeled blockers were included to preven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2023
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 1B(Rat)
Tactogen

US Patent
LigandPNGBDBM620422(US11767305, Compound R-5-MAPB | US20250019357, Com...)
Affinity DataEC50:  981nMAssay Description:The 5-HT1BR cAMP secondary messenger agonist assay used a panel of CHO-K1 cell lines stably expressing non-tagged GPCRs that endogenously signal thro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetSodium-dependent serotonin transporter(Human)
Tactogen

US Patent
LigandPNGBDBM620422(US11767305, Compound R-5-MAPB | US20250019357, Com...)
Affinity DataIC50: 2.70E+3nMAssay Description:Benzofuran derivatives were evaluated for inhibiting the human 5-HT transporter (hSERT) as expressed in CHO cells using an antagonist radioligand ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetSodium-dependent serotonin transporter(Human)
Tactogen

US Patent
LigandPNGBDBM620422(US11767305, Compound R-5-MAPB | US20250019357, Com...)
Affinity DataIC50: 150nMAssay Description:Benzofuran derivatives were evaluated for inhibiting the human 5-HT transporter (hSERT) as expressed in CHO cells using an antagonist radioligand ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetSodium-dependent serotonin transporter(Human)
Tactogen

US Patent
LigandPNGBDBM620422(US11767305, Compound R-5-MAPB | US20250019357, Com...)
Affinity DataEC50:  29.3nMAssay Description:Benzofuran derivatives were evaluated for inhibiting the human 5-HT transporter (hSERT) as expressed in CHO cells using an antagonist radioligand ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetSodium-dependent serotonin transporter(Human)
Tactogen

US Patent
LigandPNGBDBM620422(US11767305, Compound R-5-MAPB | US20250019357, Com...)
Affinity DataKi:  1.20E+3nMAssay Description:Benzofuran derivatives were evaluated for inhibiting the human 5-HT transporter (hSERT) as expressed in CHO cells using an antagonist radioligand ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent