BDBM562826 (5R,6S)-6-(3-Chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2,2-dimethylthiomorpholine-3-one 1,1-dioxide::US11407721, Example 73

SMILES CC1(C)C(=O)N(CC2CC2)[C@@H]([C@H](c2cccc(Cl)c2)S1(=O)=O)c1ccc(Cl)cc1

InChI Key InChIKey=HVHAGGDWFLSMMK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 562826   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandPNGBDBM562826(US11407721, Example 73 | (5R,6S)-6-(3-Chlorophenyl...)
Affinity DataIC50: 466nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandPNGBDBM562826(US11407721, Example 73 | (5R,6S)-6-(3-Chlorophenyl...)
Affinity DataIC50: 2.74E+3nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
Go to US Patent