BDBM562824 (S)-2-((2S,3R,6S)-2,3-Bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxomorpholino)-2-cyclopropylacetic acid::US11407721, Example 71

SMILES OC(=O)[C@H](C1CC1)N1[C@H]([C@H](O[C@H](Cc2ccc(cc2)C#N)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1

InChI Key InChIKey=MURGPOPKNPYXAX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 562824   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandPNGBDBM562824(US11407721, Example 71 | (S)-2-((2S,3R,6S)-2,3-Bis...)
Affinity DataIC50: 952nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandPNGBDBM562824(US11407721, Example 71 | (S)-2-((2S,3R,6S)-2,3-Bis...)
Affinity DataIC50: 544nMAssay Description:This assay was run using the same conditions as the HTRF1 assay except that 20 uL of GST-hMDM2 was incubated with 1.0 ul of diluted compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
Go to US Patent