BDBM562801 US11407721, Example 48

SMILES CCC[C@@H](N1[C@@H]([C@@H](O[C@@H](Cc2cccc(F)c2)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(O)=O

InChI Key InChIKey=WDHFWCFVVPABNM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 562801   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandPNGBDBM562801(US11407721, Example 48)
Affinity DataIC50: 420nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
Go to US Patent