BDBM562783 (R)-2-((2S,3R,6S)-2-(4-Chloro-3-fluorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholino)pentanoic acid and (S)-2-((2R,3S,6R)-2-(4-chloro-3-fluorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholino)pentanoic acid or (S)-2-((2S,3R,6S)-2-(4-chloro-3-fluorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholino)pentanoic acid and (R)-2-((2R,3S,6R)-2-(4-chloro-3-fluorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholino)pentanoic acid::US11407721, Example 29
SMILES CCC[C@@H](N1[C@H]([C@H](O[C@H](Cc2ccc(F)cc2)C1=O)c1ccc(Cl)c(F)c1)c1ccc(Cl)cc1)C(O)=O
InChI Key InChIKey=JGSDUUHREWFLDE-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 562783
Affinity DataIC50: 565nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair
Affinity DataIC50: 1.09E+3nMAssay Description:This assay was run using the same conditions as the HTRF1 assay except that 20 uL of GST-hMDM2 was incubated with 1.0 ul of diluted compound.More data for this Ligand-Target Pair