BDBM562778 (2S,5R,6S)-6-(3-Chlorophenyl)-5-(4-chlorophenyl)-4-isobutyl-3-oxomorpholin-2-yl)acetic acid and (2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-isobutyl-3-oxomorpholin-2-yl)acetic acid::US11407721, Example 24

SMILES CC(C)CN1[C@@H]([C@@H](O[C@@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1

InChI Key InChIKey=PJRCQJUSRZLUKY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 562778   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandPNGBDBM562778(US11407721, Example 24 | (2S,5R,6S)-6-(3-Chlorophe...)
Affinity DataIC50: 492nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandPNGBDBM562778(US11407721, Example 24 | (2S,5R,6S)-6-(3-Chlorophe...)
Affinity DataIC50: 2.15E+3nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandPNGBDBM562778(US11407721, Example 24 | (2S,5R,6S)-6-(3-Chlorophe...)
Affinity DataIC50: 2.38E+3nMAssay Description:This assay was run using the same conditions as the HTRF1 assay except that 20 uL of GST-hMDM2 was incubated with 1.0 ul of diluted compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
Go to US Patent