BDBM512913 US11091444, Compound FAH-3::US11142505, FAH #3

SMILES CN1C(N)=NC(C1=O)(c1ccc(OC(F)F)c(C)c1)c1cc(F)cc(F)c1

InChI Key InChIKey=GDKGAYIPAAQPCP-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 512913   

TargetAmyloid-beta precursor protein(Human)
Buck Institute For Research On Aging

US Patent
LigandPNGBDBM512913(US11142505, FAH #3 | US11091444, Compound FAH-3)
Affinity DataIC50: 520nMAssay Description:β-sectretase inhibitor IV from Calbiochem (cat #565788).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
Go to US Patent

TargetAmyloid-beta precursor protein(Human)
Buck Institute For Research On Aging

US Patent
LigandPNGBDBM512913(US11142505, FAH #3 | US11091444, Compound FAH-3)
Affinity DataKd:  300nMAssay Description:β-sectretase inhibitor IV from Calbiochem (cat #565788).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
University of California

US Patent
LigandPNGBDBM512913(US11142505, FAH #3 | US11091444, Compound FAH-3)
Affinity DataIC50: 530nMAssay Description:Approximately 200 nM to 10 μM substrate, approximately 10 to 200 pM enzyme, and approximately 0.1 nM to 10 μM of the agent(s), in aqueous s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
University of California

US Patent
LigandPNGBDBM512913(US11142505, FAH #3 | US11091444, Compound FAH-3)
Affinity DataIC50: 710nMAssay Description:Approximately 200 nM to 10 μM substrate, approximately 10 to 200 pM enzyme, and approximately 0.1 nM to 10 μM of the agent(s), in aqueous s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
Go to US Patent