BDBM50630495 CHEMBL5409389

SMILES CC(C)OC(=O)[C@@H](Cc1ncccn1)OC(=O)Nc1c2CCCc2cc2CCCc12

InChI Key InChIKey=UMUQEMHROZVOTF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50630495   

LigandPNGBDBM50630495(CHEMBL5409389)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-activated human PBMC cells assessed as inhibition of ATP/nigericin induced IL-1beta secretion prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630495(CHEMBL5409389)
Affinity DataIC50: 7nMAssay Description:Inhibition of NLRP3 inflammasome activation in human whole blood assessed as inhibition of LPS/ATP induced IL-1beta secretion preincubated with LPS f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630495(CHEMBL5409389)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-induced human THP-1 cells expressing GFP-tagged ASC assessed as disruption of ASC speck formation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed